Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365613 | 0.90 | FAAH (0.40) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19670375 | 0.88 | TRPV1 (0.41) | TRPM8TRPV1GSK3BDYRK1AAR | |
| SCHEMBL19670374 | 0.86 | TRPV1 (0.48) | TRPM8TRPV1ARPTGS1PTGS2 | |
| SCHEMBL19365426 | 0.86 | GSK3B (0.41) | TRPV1KCNH2GSK3BDYRK1APTGS1 | |
| SCHEMBL19670150 | 0.84 | IRAK4 (0.40) | TRPV1KCNH2GSK3B | |
| SCHEMBL16776480 | 0.84 | TRPM8 (0.42) | TRPM8TRPV1EPHX2KCNH2CACNA1C | |
| SCHEMBL19365276 | 0.84 | WNT3A (0.41) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19365317 | 0.84 | GSK3B (0.39) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19670528 | 0.83 | GSK3B (0.40) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19670162 | 0.82 | TRPV1 (0.39) | TRPM8TRPV1PHGDHGSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |