Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365276 | 0.88 | WNT3A (0.41) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19365445 | 0.88 | TRPM8 (0.43) | TRPV1GSK3BDYRK1AARTRPM8 | |
| SCHEMBL19365613 | 0.86 | FAAH (0.40) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19670623 | 0.86 | KARS1 (0.38) | TRPV1GSK3BDYRK1AAR | |
| SCHEMBL19670149 | 0.85 | FGFR4 (0.39) | GSK3BKIT | |
| SCHEMBL19670150 | 0.85 | IRAK4 (0.40) | TRPV1GSK3BSCN9ACYP1A2HTR2A | |
| SCHEMBL19365317 | 0.85 | GSK3B (0.39) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19670498 | 0.84 | KARS1 (0.41) | TRPV1GSK3BDYRK1APTGS1PTGS2 | |
| SCHEMBL19670374 | 0.84 | TRPV1 (0.48) | TRPV1ARSCN9ATRPM8PTGS1 | |
| SCHEMBL19670377 | 0.83 | CRACR2A (0.35) | TRPV3CCNA2CDK2CCNA1MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |