Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 3/20 | 0.40 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.35 |
| ▸ | PTGES | O14684 | 2/20 | 0.33 |
| ▸ | PPIA | P62937 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670554 | 0.89 | MGLL (0.40) | MGLLBTKEPHB4PTGESRAF1 | |
| SCHEMBL19706124 | 0.80 | MGLL (0.45) | MGLLHDAC1PTGESHDAC2DCUN1D1 | |
| SCHEMBL19670547 | 0.75 | MGLL (0.39) | MGLLBTKEPHB4PTGESRAF1 | |
| SCHEMBL19706296 | 0.75 | POLB (0.39) | HDAC1HDAC6EPHB4DCUN1D1 | |
| SCHEMBL16249968 | 0.74 | MGLL (0.39) | MGLLBTKEPHB4PTGESRAF1 | |
| SCHEMBL19365753 | 0.73 | CA12 (0.41) | HDAC1 | |
| SCHEMBL19670382 | 0.72 | NPY5R (0.42) | EPHB4RAF1BRAF | |
| SCHEMBL19699106 | 0.70 | MGLL (0.43) | MGLLPTGESRAF1BRAF | |
| SCHEMBL19365619 | 0.70 | KMO (0.37) | BTKEPHB4BRAF | |
| SCHEMBL19670450 | 0.70 | MEN1 (0.41) | HDAC6EPHB4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |