Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | VNN1 | O95497 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670398 | 0.86 | CTSK (0.38) | CA12CA1CA2CA9EPHB4 | |
| SCHEMBL19365753 | 0.86 | CA12 (0.41) | CA12CA1CA2CA9SIGMAR1 | |
| SCHEMBL19365617 | 0.85 | KMO (0.39) | MEN1KMT2ACA12CA1CA2 | |
| SCHEMBL19365661 | 0.83 | MEN1 (0.39) | MEN1KMT2ATRPV1CDK8CA12 | |
| SCHEMBL19670322 | 0.82 | MAPK1 (0.38) | KDM4EMAPTHPGDEPHB4NAMPT | |
| SCHEMBL19670534 | 0.78 | DGAT2 (0.41) | EPHB4NAMPTPIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365828 | 0.76 | CA12 (0.46) | CDK8CA12CA1CA2CA9 | |
| SCHEMBL19365825 | 0.74 | MCHR1 (0.40) | TRPV1CA12CA1CA2CA9 | |
| SCHEMBL19365558 | 0.73 | KDR (0.40) | KDM4EEPHB4PIK3CDPIK3CAPIK3CG | |
| SCHEMBL19365619 | 0.73 | KMO (0.37) | CA2CA9EPHB4PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |