Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670168 | 0.88 | IRAK4 (0.43) | KCNH2FYNPIM1FLT3PIM2 | |
| SCHEMBL19670228 | 0.88 | NPC1 (0.38) | ALDH1A1MAPT | |
| SCHEMBL19365904 | 0.87 | MAPT (0.43) | MEN1ALDH1A1KMT2AMAPTFYN | |
| SCHEMBL19670246 | 0.86 | SCN9A (0.39) | ADORA2AKDM1AMAPTFYNMAOA | |
| SCHEMBL19670418 | 0.86 | MPL (0.42) | ADORA2AKDM1AMAPTFYNMAOA | |
| SCHEMBL17618359 | 0.85 | KMT2A (0.39) | ADORA2AKCNH2KDM1AJAK2MEN1 | |
| SCHEMBL19365368 | 0.85 | TRPA1 (0.38) | ADORA2AKCNH2KDM1AJAK2MEN1 | |
| SCHEMBL19365708 | 0.85 | MAPT (0.41) | ADORA2AKDM1AJAK2MEN1ALDH1A1 | |
| SCHEMBL19365316 | 0.84 | NPC1 (0.38) | ADORA2AKDM1AMEN1ALDH1A1KMT2A | |
| SCHEMBL16775838 | 0.83 | KCNH2 (0.39) | ADORA2AKCNH2KDM1AJAK2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |