Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 6/20 | 0.35 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365596 | 0.88 | ADORA2A (0.39) | MAPTALDH1A1 | |
| SCHEMBL19670168 | 0.86 | IRAK4 (0.43) | — | |
| SCHEMBL19670359 | 0.85 | CLK2 (0.40) | MAPTSMN1; SMN2HSD11B1GRM5CNR2 | |
| SCHEMBL17618439 | 0.84 | RAB9A (0.39) | NPC1RAB9AMAPTSMN1; SMN2HSD11B1 | |
| SCHEMBL19670146 | 0.82 | TSHR (0.45) | NPC1RAB9AMAPTSMN1; SMN2GRM5 | |
| SCHEMBL19670432 | 0.79 | TRPV3 (0.34) | NPC1RAB9A | |
| SCHEMBL19670172 | 0.79 | ADORA2A (0.37) | SYK | |
| SCHEMBL19365317 | 0.77 | GSK3B (0.39) | NPC1RAB9ASMN1; SMN2CNR2TSHR | |
| SCHEMBL19365432 | 0.77 | MDM2 (0.39) | MAPTGRM5CNR2ALDH1A1 | |
| SCHEMBL19365613 | 0.76 | FAAH (0.40) | NPC1RAB9ACNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |