Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.38 |
| ▸ | CPT2 | P23786 | 2/20 | 0.37 |
| ▸ | CPT1A | P50416 | 2/20 | 0.37 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670246 | 0.88 | SCN9A (0.39) | FYNSCN9ACA2CA9ADORA2A | |
| SCHEMBL19365708 | 0.86 | MAPT (0.41) | FYNCA2CA9ADORA2AKDM1A | |
| SCHEMBL12654396 | 0.86 | MPL (0.45) | MPLFYNSCN9ACPT2CPT1A | |
| SCHEMBL19365745 | 0.86 | DHFR (0.38) | ARFAAH | |
| SCHEMBL19365596 | 0.86 | ADORA2A (0.39) | FYNKMOCA2CA9ADORA2A | |
| SCHEMBL19365904 | 0.85 | MAPT (0.43) | FYNCA2CA9MAPTFAAH | |
| SCHEMBL19365457 | 0.85 | MAPT (0.38) | FYNCPT1AKMOCA2CA9 | |
| SCHEMBL19365254 | 0.85 | HTR2C (0.47) | MAPTFAAH | |
| SCHEMBL16775973 | 0.85 | MPL (0.44) | MPLFYNSCN9ACPT2CPT1A | |
| SCHEMBL19670144 | 0.85 | CHRM4 (0.37) | KMOCA2CA9KDM1AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |