Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 4/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.39 |
| ▸ | BLM | P54132 | 6/20 | 0.39 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | WRN | Q14191 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | USP8 | P40818 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17618860 | 0.86 | MAPK10 (0.38) | MAPK10MAPK8BLMIDEMAPK1 | |
| SCHEMBL19670476 | 0.83 | TRPV1 (0.46) | MAPK1WNT3A | |
| SCHEMBL19670497 | 0.83 | MAPT (0.45) | KDM4EUSP2SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL19365629 | 0.81 | CHRM4 (0.41) | — | |
| SCHEMBL17618797 | 0.81 | USP2 (0.39) | WNT3AKDM4EUSP2USP8HPGD | |
| SCHEMBL17618810 | 0.79 | KMT2A (0.40) | BLMWNT3AKDM4EUSP2USP8 | |
| SCHEMBL19670299 | 0.79 | FYN (0.43) | MAPK1KDM4ESMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL19670414 | 0.78 | ADCY1 (0.41) | MAPK1KDM4ESMN1; SMN2HSD17B10LMNA | |
| SCHEMBL19365413 | 0.78 | ADCY1 (0.50) | MAPK1KDM4EGPR65SMN1; SMN2ALDH1A1 | |
| SCHEMBL19365574 | 0.77 | CA2 (0.41) | SMN1; SMN2ALDH1A1HSD17B10KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |