Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WNT3A | P56704 | 8/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365369 | 0.90 | GSK3B (0.38) | ABL1GSK3BDYRK1AHTR2AHTR2C | |
| SCHEMBL19365620 | 0.89 | HTR2C (0.43) | WNT3AMAPK1ABL1HTR2AHTR2C | |
| SCHEMBL19670540 | 0.86 | DYRK1A (0.36) | WNT3AGRM5GSK3BDYRK1AHTR2A | |
| SCHEMBL19365654 | 0.86 | HCRTR1 (0.44) | WNT3AGRM5GRM2MAPK1HCRTR1 | |
| SCHEMBL19670206 | 0.85 | DYRK1A (0.34) | GSK3BDYRK1A | |
| SCHEMBL19670010 | 0.85 | CLK2 (0.34) | ABL1DYRK1A | |
| SCHEMBL19365270 | 0.84 | WNT3A (0.40) | WNT3AGRM5MAPK1ABL1GSK3B | |
| SCHEMBL19365595 | 0.84 | MAPT (0.38) | MAPK1HTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL17618520 | 0.84 | USP30 (0.37) | WNT3AUSP30GRM5PSEN1PSEN2 | |
| SCHEMBL19364877 | 0.83 | TRPV3 (0.38) | ABL1GSK3BDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |
| US-9765075-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-09-19 | — | — | US | disclosed |