Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LIG1 | P18858 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PTGIR | P43119 | 1/20 | 0.32 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL307214 | 0.74 | AGTR2 (0.43) | HSD11B1AGTR2APPMAPT | |
| SCHEMBL28238968 | 0.72 | ESR1 (0.42) | HSD11B1AGTR2TSHRHPGD | |
| SCHEMBL1266868 | 0.72 | CES2 (0.41) | APP | |
| SCHEMBL374161 | 0.71 | ALDH1A1 (0.45) | AGTR2TSHR | |
| SCHEMBL372046 | 0.68 | FAAH (0.48) | KMT2A | |
| SCHEMBL22265281 | 0.68 | HSD11B1 (0.36) | HSD11B1AGTR2MEN1MAPTRECQL | |
| SCHEMBL558091 | 0.68 | AGTR2 (0.41) | AGTR2HPGDPTGIRPTGDR | |
| SCHEMBL5807830 | 0.67 | ALDH1A1 (0.53) | MEN1MAPTKMT2A | |
| SCHEMBL754646 | 0.66 | TSHR (0.45) | TSHRAPPMEN1MAPTKMT2A | |
| SCHEMBL6423500 | 0.66 | L3MBTL1 (0.38) | HSD11B1TSHRPTGIRPTGDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2409704-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2017-09-20 | — | — | EP | disclosed |