Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | F13A1 | P00488 | 1/20 | 0.37 |
| ▸ | TGM2 | P21980 | 1/20 | 0.37 |
| ▸ | TGM1 | P22735 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL524534 | 0.87 | HDAC1 (0.39) | HDAC1TP53HRH1F13A1TGM2 | |
| SCHEMBL10102483 | 0.86 | ALDH1A1 (0.40) | HDAC1TP53HRH1F13A1TGM2 | |
| SCHEMBL19384148 | 0.85 | KDM4E (0.43) | HRH1ALDH1A1KDM4ESMN1; SMN2RBP4 | |
| SCHEMBL19384146 | 0.82 | HTR1D (0.51) | ALDH1A1KDM4ESMN1; SMN2L3MBTL1 | |
| SCHEMBL19384156 | 0.82 | CTSL (0.38) | HDAC1TP53HRH1F13A1TGM2 | |
| Trifluoroacetic Acid SCHEMBL523116 | 0.82 | RBP4 (0.39) | HDAC1TP53HRH1ALDH1A1KDM4E | |
| SCHEMBL20854266 | 0.77 | F13A1 (0.39) | TP53F13A1TGM2TGM1PDE4A | |
| SCHEMBL450708 | 0.76 | HTT (0.47) | ALDH1A1SMN1; SMN2HTTL3MBTL1 | |
| SCHEMBL29777971 | 0.75 | ALDH1A1 (0.43) | HRH1ALDH1A1KDM4ERBP4HTT | |
| SCHEMBL19384151 | 0.75 | HRH1 (0.46) | HRH1F13A1TGM2TGM1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190100498-A1 | CRYSTALLINE FORM | ASTRAZENECA AB (SE) | 2019-04-04 | — | — | US | disclosed |
| US-20190100498-A1 | CRYSTALLINE FORM | ASTRAZENECA AB (SE) | 2019-04-04 | — | — | US | disclosed |
| EP-3433237-A1 | CRYSTALLINE FORM | Astrazeneca AB (SE) | 2019-01-30 | — | — | EP | disclosed |
| WO-2017162304-A1 | CRYSTALLINE FORM | ASTRAZENECA AB (SE) | 2017-09-28 | — | — | WO | disclosed |
| WO-2017162304-A1 | CRYSTALLINE FORM | ASTRAZENECA AB (SE) | 2017-09-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190100498-A1 | CRYSTALLINE FORM | GYS2, PYGL, SFPQ | HDAC1 1506/4885TP53 637/4885HRH1 4086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.