Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | ANPEP | P15144 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA3 | P07451 | 1/20 | 0.46 |
| ▸ | TYR | P14679 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA6 | P23280 | 1/20 | 0.46 |
| ▸ | CA5A | P35218 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19133292 | 0.82 | MAPT (0.46) | ALDH1A1SMN1; SMN2KMT2AHPGDMAPK1 | |
| SCHEMBL105270 | 0.81 | RXRA (0.62) | TSHRTP53ANPEPALDH1A1SMN1; SMN2 | |
| SCHEMBL372015 | 0.81 | TSHR (0.60) | TSHRTP53ANPEPALDH1A1SMN1; SMN2 | |
| SCHEMBL31192242 | 0.81 | TSHR (0.60) | TSHRTP53ANPEPALDH1A1SMN1; SMN2 | |
| SCHEMBL20178615 | 0.81 | KDM4E (0.51) | TSHRKMT2A | |
| Terephthalic Acid SCHEMBL23071346 | 0.80 | TSHR (0.75) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Terephthalic Acid SCHEMBL28393368 | 0.80 | TSHR (0.75) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| Terephthalic Acid SCHEMBL23069370 | 0.80 | TSHR (0.75) | TSHRTP53ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9185162 | 0.79 | RXRA (0.61) | TSHRTP53ANPEPALDH1A1SMN1; SMN2 | |
| SCHEMBL6911963 | 0.79 | TSHR (0.57) | TSHRTP53ANPEPALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2022-01-18 | — | — | US | disclosed |
| EP-3270903-B1 | DISULFIDE-CONTAINING ALKYNE LINKING AGENTS | ARROWHEAD PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |
| EP-3270903-B1 | DISULFIDE-CONTAINING ALKYNE LINKING AGENTS | ARROWHEAD PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH (US) | 2018-04-19 | — | — | US | disclosed |
| US-20180023084-A1 | Disulfide-Containing Alkyne Linking Agents | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2018-01-25 | — | — | US | disclosed |
| US-20180023084-A1 | Disulfide-Containing Alkyne Linking Agents | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2018-01-25 | — | — | US | disclosed |
| EP-3270903-A1 | IMPROVED DISULFIDE-CONTAINING ALKYNE LINKING AGENTS | Arrowhead Pharmaceuticals, Inc. (US) | 2018-01-24 | — | — | EP | disclosed |
| US-9803201-B2 | Disulfide-containing alkyne linking agents | Arrowhead Pharmaceuticals, Inc. (US) | 2017-10-31 | — | — | US | disclosed |
| US-9803201-B2 | Disulfide-containing alkyne linking agents | Arrowhead Pharmaceuticals, Inc. (US) | 2017-10-31 | — | — | US | disclosed |
| WO-2016149313-A1 | IMPROVED DISULFIDE-CONTAINING ALKYNE LINKING AGENTS | ARROWHEAD RESEARCH CORPORATION (US) | 2016-09-22 | — | — | WO | disclosed |
| US-20160272971-A1 | Disulfide-Containing Alkyne Linking Agents | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2016-09-22 | — | — | US | disclosed |
| US-20160272971-A1 | Disulfide-Containing Alkyne Linking Agents | SIXTH STREETLENDING PARTNERS, AS THE ADMINISTRATIVE AGENT | 2016-09-22 | — | — | US | disclosed |
| US-20110172126-A1 | LIBRARIES OF PEPTIDE CONJUGATES AND METHODS FOR MAKING THEM | XENOME LTD (AU) | 2011-07-14 | — | — | US | disclosed |
| EP-2331561-A1 | LIBRARIES OF PEPTIDE CONJUGATES AND METHODS FOR MAKING THEM | Xenome Ltd (AU) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010025510-A1 | LIBRARIES OF PEPTIDE CONJUGATES AND METHODS FOR MAKING THEM | XENOME LTD (AU) | 2010-03-11 | — | — | WO | disclosed |
| US-7220758-B2 | Ether substituted imidazopyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2007-05-22 | — | — | US | disclosed |
| US-20060252792-A1 | ETHER SUBSTITUTED IMIDAZOPYRIDINES | 3M INNOVATIVE PROPERTIES COMPANY | 2006-11-09 | — | — | US | disclosed |
| US-7125890-B2 | Ether substituted imidazopyridines | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-10-24 | — | — | US | disclosed |
| US-20050032830-A1 | Immunology for viral diseases and biosynthesis of cytokines of anticancer drugs for tumors | 3M INNOVATIVE PROPERTIES COMPANY | 2005-02-10 | — | — | US | disclosed |
| US-6797718-B2 | Ether substituted imidazopyridines | 3M INNOVATIVE PROPERTIES COMPANY | 2004-09-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11225469-B2 | Inhibitors of phosphoglycerate dehydrogenase (PHGDH) and uses thereof | PHGDH, PGD, PGK1 | TSHR 3004/4885TP53 297/4885ANPEP 3506/4885 |
| US-20060252792-A1 | ETHER SUBSTITUTED IMIDAZOPYRIDINES | IL2, IL4, MYD88 | TSHR 893/4885TP53 226/4885ANPEP 1059/4885 |
| US-20180105508-A1 | INHIBITORS OF PHOSPHOGLYCERATE DEHYDROGENASE (PHGDH) AND USES THEREOF | PHGDH, PGD, PGK1 | TSHR 2549/4885TP53 245/4885ANPEP 3458/4885 |
| US-20050032830-A1 | Immunology for viral diseases and biosynthesis of cytokines of anticancer drugs for tumors | IL2, IFNG, TSLP | TSHR 938/4885TP53 111/4885ANPEP 556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.