Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7213440 | 0.81 | AKT1 (0.56) | PTGDR2METAP2CYP19A1L3MBTL1MAPK1 | |
| SCHEMBL16180643 | 0.79 | DYRK1A (0.41) | PTGDR2TSHRCYP1A2CYP3A4CYP2D6 | |
| Benzene SCHEMBL29266805 | 0.76 | USP7 (0.59) | BACE1MAP4K4 | |
| SCHEMBL28410815 | 0.74 | METAP2 (0.43) | PTGDR2METAP2CYP19A1L3MBTL1MAPK1 | |
| SCHEMBL3838001 | 0.73 | AKT1 (0.53) | METAP2AKT1ADORA1NPSR1 | |
| SCHEMBL18587832 | 0.73 | MAOA (0.56) | PTGDR2METAP2CYP19A1BACE1MEN1 | |
| SCHEMBL2571411 | 0.71 | ALOX5 (0.55) | PTGDR2CYP19A1BACE1TSHRMEN1 | |
| SCHEMBL3837608 | 0.70 | AKT1 (0.58) | PTGDR2METAP2CYP19A1AKT1TSHR | |
| SCHEMBL30656042 | 0.70 | ADORA2A (0.50) | L3MBTL1AKT1GABRA1GABRG2GABRB3 | |
| SCHEMBL27241759 | 0.70 | ALDH1A1 (0.65) | L3MBTL1GABRA1GABRG2GABRB3GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1622616-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2011-06-15 | — | — | EP | disclosed |
| EP-1622616-B1 | INHIBITORS OF AKT ACTIVITY | MERCK SHARP & DOHME (US) | 2011-06-15 | — | — | EP | disclosed |
| EP-1631548-B1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2009-10-28 | — | — | EP | disclosed |
| EP-1631548-B1 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2009-10-28 | — | — | EP | disclosed |
| US-7579355-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-7579355-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-7414055-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414055-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2008-08-19 | — | — | US | disclosed |
| EP-1631548-A4 | INHIBITORS OF AKT ACTIVITY | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-20070043001-A1 | Inhibitors of akt activity | MERCK SHARP & DOHME CORP. | 2007-02-22 | — | — | US | disclosed |
| US-20070043001-A1 | Inhibitors of akt activity | MERCK SHARP & DOHME CORP. | 2007-02-22 | — | — | US | disclosed |
| US-20060270673-A1 | Inhibitors of akt activity | MERCK & CO., INC. (US) | 2006-11-30 | — | — | US | disclosed |
| EP-1631548-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2006-03-08 | — | — | EP | disclosed |
| EP-1622616-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2006-02-08 | — | — | EP | disclosed |
| WO-2004096135-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2004-11-11 | — | — | WO | disclosed |
| WO-2004096131-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2004-11-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060270673-A1 | Inhibitors of akt activity | AKT1, AKT2, AKT3 | PTGDR2 4460/4885METAP2 2343/4885CYP19A1 2479/4885 |
| US-20070043001-A1 | Inhibitors of akt activity | MTMR1, PIK3CA, PLK1 | PTGDR2 4561/4885METAP2 1305/4885CYP19A1 2618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.