4'-Thiothymidine

4'-Thiothymidine

SCHEMBL1942500

Cc1cn([C@H]2C[C@H](O)[C@@H](CO)S2)c(=O)[nH]c1=O

nearest known ligand 0.54

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TK1 P04183 5/20 0.49
ALDH1A1 P00352 1/20 0.49
LMNA P02545 1/20 0.49
ALB P02768 1/20 0.49
POLB P06746 1/20 0.49
ADRA1A P35348 1/20 0.49
BLM P54132 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
4'-Thiothymidine SCHEMBL6266871 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL3517583 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL13083838 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL23897578 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL6311407 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL23897630 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL3517588 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL9520953 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL12642446 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB
4'-Thiothymidine SCHEMBL30381070 1.00 TK1 (0.49) TK1ALDH1A1LMNAALBPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2331106-B1 NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS IMP INNOVATIONS LTD (GB) 2012-10-10 EP claimed
US-20110236312-A1 NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS IMPERIAL INNOVATIONS LIMITED (GB) 2011-09-29 US claimed
EP-2331106-A1 NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS Imperial Innovations Limited (GB) 2011-06-15 EP claimed
WO-2010023457-A1 NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS IMPERIAL INNOVATIONS LIMITED (GB) 2010-03-04 WO claimed
US-5591722-A ANTICANCER AGENTS SOUTHERN RESEARCH INSTITUTE (US) 1997-01-07 US claimed
EP-0491793-A4 2'-DEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AND ANTICANCER AGENTS 1993-03-03 EP claimed
EP-0491793-A1 2'-DEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AND ANTICANCER AGENTS SOUTHERN RESEARCH INSTITUTE (US) 1992-07-01 EP claimed
WO-1991004033-A1 2'-DEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AND ANTICANCER AGENTS SOUTHERN RESEARCH INSTITUTE (US) 1991-04-04 WO claimed
EP-3680334-B1 DOUBLE-STRANDED RNA MOLECULE TARGETING CKIP-1 AND USE THEREOF BEIJING TIDE PHARMACEUTICAL CO LTD (CN) 2026-03-25 EP disclosed
EP-4713477-A1 DETECTION OF TARGET ANALYTES USING MULTIMODAL SIGNAL PROBES Roche Molecular Systems, Inc. (US) 2026-03-25 EP disclosed
US-20250354201-A1 FERROCENE LABELLED PRIMERS FOR ELECTROCHEMICAL DETECTION ROCHE MOLECULAR SYSTEMS INC (US) 2025-11-20 US disclosed
EP-4536852-A1 FERROCENE LABELLED PRIMERS FOR ELECTROCHEMICAL DETECTION F. Hoffmann-La Roche AG (CH) 2025-04-16 EP disclosed
CN-119343463-A Ferrocene-labeled primers for electrochemical detection 豪夫迈·罗氏有限公司 2025-01-21 CN disclosed
WO-2024235904-A1 DETECTION OF TARGET ANALYTES USING MULTIMODAL SIGNAL PROBES ROCHE MOLECULAR SYSTEMS, INC. (US) 2024-11-21 WO disclosed
US-5478928-A Useful as antiviral agents in the treatment and prevention of AIDS SOUTHERN RESEARCH INSTITUTE (US) 1995-12-26 US disclosed
WO-1993016095-A1 OLIGOTHIONUCLEOTIDES CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) 1993-08-19 WO disclosed
EP-0491793-A4 2'-DEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AND ANTICANCER AGENTS 1993-03-03 EP disclosed
US-5128458-A 2',3'-dideoxy-4'-thioribonucleosides as antiviral agents SOUTHERN RESEARCH INSTITUTE (US) 1992-07-07 US disclosed
EP-0491793-A1 2'-DEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AND ANTICANCER AGENTS SOUTHERN RESEARCH INSTITUTE (US) 1992-07-01 EP disclosed
WO-1991004033-A1 2'-DEOXY-4'-THIORIBONUCLEOSIDES AS ANTIVIRAL AND ANTICANCER AGENTS SOUTHERN RESEARCH INSTITUTE (US) 1991-04-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110236312-A1 NUCLEOSIDE ANALOGUES USEFUL AS POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS TYMP, SLC29A1, NT5C3B TK1 16/4885ALDH1A1 2290/4885LMNA 3864/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.