Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.44 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11980693 | 0.87 | TDP1 (0.57) | KDM4EALDH1A1TSHRKMT2ATHRB | |
| SCHEMBL11985078 | 0.85 | HTT (0.60) | CASP6HTTSMN1; SMN2RAB9AMAPK1 | |
| SCHEMBL27859664 | 0.81 | HTT (0.71) | KDM4EALDH1A1THRBHTTPOLB | |
| SCHEMBL992344 | 0.80 | KMT2A (0.47) | KDM4EALDH1A1TSHRKMT2ATHRB | |
| SCHEMBL12950492 | 0.79 | THRB (0.44) | KDM4EALDH1A1TSHRKMT2ATHRB | |
| SCHEMBL19442008 | 0.79 | RAB9A (0.60) | KDM4EALDH1A1KMT2ATDP1POLB | |
| SCHEMBL19442006 | 0.76 | ALDH1A1 (0.69) | ALDH1A1RAB9AMAPK1 | |
| SCHEMBL15268192 | 0.75 | CASP6 (0.46) | KDM4EALDH1A1TSHRKMT2ACASP6 | |
| SCHEMBL19442078 | 0.72 | KMT2A (0.62) | KDM4EALDH1A1TSHRKMT2ACASP6 | |
| SCHEMBL11985172 | 0.71 | POLB (0.61) | KDM4EALDH1A1KMT2ATDP1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782382-B2 | TOFA analogs useful in treating dermatological disorders or conditions | DERMIRA (CANADA), INC. (US) | 2017-10-10 | — | — | US | disclosed |