Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.60 |
| ▸ | GRM5 | P41594 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | ME2 | P23368 | 1/20 | 0.51 |
| ▸ | ME1 | P48163 | 1/20 | 0.51 |
| ▸ | ME3 | Q16798 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11980694 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HSD17B10GRM5MAPTNPC1 | |
| SCHEMBL19442008 | 0.83 | RAB9A (0.60) | ALDH1A1NPC1RAB9AL3MBTL1LMNA | |
| SCHEMBL11985078 | 0.82 | HTT (0.60) | MAPTNPC1RAB9AL3MBTL1MAPK1 | |
| SCHEMBL27876284 | 0.81 | ALDH1A1 (1.00) | ALDH1A1HSD17B10GRM5MAPTNPC1 | |
| SCHEMBL1079065 | 0.79 | ALDH1A1 (0.57) | ALDH1A1HSD17B10GRM5MAPTNPC1 | |
| SCHEMBL11985172 | 0.78 | POLB (0.61) | ALDH1A1MAPTNPC1RAB9AL3MBTL1 | |
| SCHEMBL15268192 | 0.77 | CASP6 (0.46) | ALDH1A1MAPTRAB9A | |
| SCHEMBL19442012 | 0.76 | KDM4E (0.50) | ALDH1A1RAB9AMAPK1 | |
| SCHEMBL11985253 | 0.75 | MAPT (0.42) | ALDH1A1GRM5MAPTMAPK1 | |
| SCHEMBL10983798 | 0.74 | MAPT (0.57) | ALDH1A1HSD17B10GRM5MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9782382-B2 | TOFA analogs useful in treating dermatological disorders or conditions | DERMIRA (CANADA), INC. (US) | 2017-10-10 | — | — | US | disclosed |