Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960261 | 0.79 | RAB9A (0.36) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL24671629 | 0.74 | KIF11 (0.49) | RAB9A | |
| SCHEMBL29954766 | 0.74 | KIF11 (0.49) | RAB9A | |
| SCHEMBL18379360 | 0.68 | GABRA1 (0.32) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL1615765 | 0.67 | GABRA1 (0.46) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL5016542 | 0.67 | KDM4E (0.37) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL8479941 | 0.66 | GABRA1 (0.47) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL11887259 | 0.65 | ALDH1A1 (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL29955256 | 0.64 | CREBBP (0.48) | RAB9A | |
| SCHEMBL11888497 | 0.63 | ALDH1A1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3442980-A1 | HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | Cancer Research Technology Limited (GB) | 2019-02-20 | — | — | EP | disclosed |
| WO-2017178844-A1 | HETEROCYCLIC COMPOUNDS AS RET KINASE INHIBITORS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2017-10-19 | — | — | WO | disclosed |