Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19954179 | 0.85 | PARP1 (0.45) | PARP1ALDH1A1TRPV6LMNASMN1; SMN2 | |
| SCHEMBL178440 | 0.80 | LOXL2 (0.41) | PARP1ALDH1A1TRPV6LMNAGAA | |
| SCHEMBL12844536 | 0.78 | GPR84 (0.42) | ALDH1A1TRPV6LMNAMEN1KMT2A | |
| SCHEMBL313756 | 0.77 | — | — | |
| SCHEMBL20988117 | 0.77 | KDM4E (0.40) | PARP1ALDH1A1TRPV6LMNAGAA | |
| SCHEMBL4827198 | 0.76 | ALDH1A1 (0.40) | ALDH1A1TRPV6LMNAGAASMN1; SMN2 | |
| SCHEMBL19090766 | 0.75 | CYP2D6 (0.41) | PARP1ALDH1A1TRPV6LMNAGAA | |
| SCHEMBL15934339 | 0.75 | LMNA (0.41) | ALDH1A1LMNAGAASMN1; SMN2MEN1 | |
| SCHEMBL19954180 | 0.75 | TRPV6 (0.39) | ALDH1A1TRPV6LMNAGAASMN1; SMN2 | |
| SCHEMBL1196047 | 0.74 | KMT2A (0.51) | ALDH1A1LMNAGAASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017181177-A1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | Epizyme, Inc. (US) | 2017-10-19 | — | — | WO | disclosed |