Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PGK1 | P00558 | 1/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24076841 | 0.81 | CRHBP (0.33) | CYP1A2CYP3A4CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL20663170 | 0.77 | TRIM58 (0.36) | TRIM58CYP1A2CYP3A4CYP2C19ACVR2A | |
| SCHEMBL23758188 | 0.75 | ALDH1A1 (0.38) | ALDH1A1CYP3A4CYP2C19HSD17B10KDM4E | |
| SCHEMBL25523664 | 0.74 | TRIM58 (0.34) | TRIM58CYP1A2CYP3A4CYP2C19ACVR2A | |
| SCHEMBL3139494 | 0.73 | ALDH1A1 (0.44) | ALDH1A1LRRK2JAK2ACVR2ATGFBR1 | |
| SCHEMBL25711816 | 0.73 | NCF1 (0.43) | ALDH1A1TRIM58TDP1KDM4ELMNA | |
| SCHEMBL15596165 | 0.73 | ALDH1A1 (0.39) | ALDH1A1TDP1 | |
| SCHEMBL7969276 | 0.72 | LCK (0.40) | MAP4K4LMNAMEN1GAAKMT2A | |
| SCHEMBL16261557 | 0.71 | LRRK2 (0.37) | ALDH1A1LRRK2JAK2CYP1A2CYP3A4 | |
| SCHEMBL1502908 | 0.69 | SIRT2 (0.38) | ALDH1A1LRRK2JAK2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017181177-A1 | AMINE-SUBSTITUTED ARYL OR HETEROARYL COMPOUNDS AS EHMT1 AND EHMT2 INHIBITORS | Epizyme, Inc. (US) | 2017-10-19 | — | — | WO | disclosed |