Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM58 | Q8NG06 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 4/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.33 |
| ▸ | ESRRB | O95718 | 1/20 | 0.33 |
| ▸ | ESRRA | P11474 | 1/20 | 0.33 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NCF1 | P14598 | 1/20 | 0.31 |
| ▸ | USP7 | Q93009 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19477494 | 0.77 | ALDH1A1 (0.38) | TRIM58ACVR2ATGFBR1KDM4ELMNA | |
| SCHEMBL25523664 | 0.74 | TRIM58 (0.34) | TRIM58ACVR2ATGFBR1KDM4ELMNA | |
| SCHEMBL25711816 | 0.73 | NCF1 (0.43) | TRIM58KDM4ELMNAMEN1POLB | |
| SCHEMBL21284326 | 0.68 | KDM4E (0.36) | TRIM58ACVR2ATGFBR1KDM4ELMNA | |
| SCHEMBL20881196 | 0.68 | CYP1A2 (0.42) | KDM4EMEN1CYP1A2GAAKMT2A | |
| SCHEMBL20829977 | 0.67 | ACVR2A (0.33) | TRIM58ACVR2ATGFBR1 | |
| SCHEMBL7118798 | 0.65 | KMT2A (0.36) | KDM4ELMNAMEN1CYP1A2CYP3A4 | |
| SCHEMBL3139494 | 0.65 | ALDH1A1 (0.44) | ACVR2ATGFBR1MEN1KMT2A | |
| SCHEMBL23283536 | 0.64 | NCF1 (0.45) | CYP1A2CYP3A4CYP2C19NCF1 | |
| SCHEMBL24879009 | 0.63 | ACVR2A (0.33) | ACVR2ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791137-B1 | PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2019-01-23 | — | — | EP | disclosed |