Sugi Predict

Sugi Predict / Compounds / SCHEMBL1948795

SCHEMBL1948795

SCHEMBL1948795

CC(C)(C)OC(=O)NOC(=O)c1ccccc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 2/20 0.58
▸ KMT2A Q03164 2/20 0.58
▸ MAPT P10636 2/20 0.58
▸ POLB P06746 1/20 0.58
▸ TDP1 Q9NUW8 3/20 0.51
▸ TSHR P16473 2/20 0.51
▸ HSD17B10 Q99714 1/20 0.51
▸ CA12 O43570 2/20 0.46
▸ CA1 P00915 2/20 0.46
▸ CA2 P00918 1/20 0.46
▸ CA9 Q16790 1/20 0.46
▸ PPARG P37231 3/20 0.44
▸ PPARA Q07869 3/20 0.44
▸ PPARD Q03181 2/20 0.44
▸ F2 P00734 1/20 0.44
▸ LMNA P02545 1/20 0.44
▸ MEN1 O00255 1/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ GAA P10253 1/20 0.43
▸ RAB9A P51151 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12067919 0.85 TDP1 (0.52) ALDH1A1KMT2AMAPTPOLBTDP1
SCHEMBL28238655 0.84 ALDH1A1 (0.47) ALDH1A1KMT2AMAPTPOLBTDP1
SCHEMBL13595527 0.83 CA1 (0.44) ALDH1A1KMT2AMAPTPOLBCA12
SCHEMBL29499830 0.83 TDP1 (0.49) ALDH1A1KMT2AMAPTPOLBTDP1
SCHEMBL13595529 0.83 RAB9A (0.49) ALDH1A1KMT2AMAPTPOLBCA12
SCHEMBL14344864 0.83 CA12 (0.44) ALDH1A1KMT2AMAPTPOLBCA12
SCHEMBL13595532 0.83 KMT2A (0.44) ALDH1A1KMT2AMAPTPOLBCA12
SCHEMBL12067869 0.83 ALDH1A1 (0.53) ALDH1A1KMT2AMAPTPOLBTSHR
SCHEMBL27642696 0.83 PARP1 (0.47) KMT2AMAPTPOLBCA12CA1
SCHEMBL13595528 0.82 CA1 (0.56) ALDH1A1KMT2AMAPTTDP1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102471341-A Compounds and compositions for the treatment of parasitic diseases IRM LLC 2012-05-23 — — CN claimed
WO-2024204554-A1 SPIROCYCLIC MORPHINAN DERIVATIVE 日本ケミファ株式会社 2024-10-03 — — WO disclosed
CN-116332935-A Synthesis method of folic acid 浙江工业大学 2023-06-27 — — CN disclosed
CN-113388004-B Tumor protease activated self-assembly molecular probe and preparation method and application thereof 江苏省原子医学研究所 2023-04-07 — — CN disclosed
EP-2509941-B1 N-ACYLATED HYDROXYLAMINE DERIVATIVES AND O-ACYLATED HYDROXYLAMINE DERIVATIVES UNIV JOHNS HOPKINS (US) 2019-01-23 — — EP disclosed
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES THE JOHNS HOPKINS UNIVERSITY 2018-02-22 — — US disclosed
EP-3131883-A1 5-HT2B ANTAGONISTS National Institute Of Biological Sciences, Beijing (CN) 2017-02-22 — — EP disclosed
US-9458127-B2 Bis-acylated hydroxylamine derivatives CARDIOXYL PHARMACEUTICALS, INC. (US) 2016-10-04 — — US disclosed
WO-2016058544-A1 INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7) SYROS PHARMACEUTICALS, INC. (US) 2016-04-21 — — WO disclosed
US-20160046570-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES THE JOHNS HOPKINS UNIVERSITY 2016-02-18 — — US disclosed
CN-102471341-A Compounds and compositions for the treatment of parasitic diseases IRM LLC 2012-05-23 — — CN disclosed
WO-2011159177-A1 IMPROVED AMINOHYDROXYLATION OF ALKENES INDUSTRIAL RESEARCH LIMITED (NZ) 2011-12-22 — — WO disclosed
US-20110144067-A1 N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives THE JOHNS HOPKINS UNIVERSITY 2011-06-16 — — US disclosed
US-20110136827-A1 Bis-Acylated Hydroxylamine Derivatives THE JOHNS HOPKINS UNIVERSITY 2011-06-09 — — US disclosed
US-20090318509-A1 Oxime Derivatives as Inhibitors of Macrophage Migration Inhibitory Factor FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE 2009-12-24 — — US disclosed
US-20090318509-A1 Oxime Derivatives as Inhibitors of Macrophage Migration Inhibitory Factor FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, THE 2009-12-24 — — US disclosed
WO-2007145888-A2 OXIME DERIVATIVES AS INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR THE FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH (US) 2007-12-21 — — WO disclosed
EP-1144365-A3 INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION TANABE SEIYAKU CO., LTD. (JP) 2003-07-09 — — EP disclosed
EP-1144365-A2 INHIBITORS OF ALPHA-4 BETA-1 MEDIATED CELL ADHESION TANABE SEIYAKU CO., LTD. (JP) 2001-10-17 — — EP disclosed
WO-2000037429-A2 INHIBITORS OF α4β1 MEDIATED CELL ADHESION TANABE SEIYAKU CO., LTD. (JP) 2000-06-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180050985-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, NOS2 ALDH1A1 648/4885KMT2A 1464/4885MAPT 4844/4885
US-20160046570-A1 N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES TNNI3, TNNT2, TNNC1 ALDH1A1 698/4885KMT2A 1413/4885MAPT 4834/4885
US-20110144067-A1 N-Acyloxysulfonamide and N-Hydroxy-N-Acylsulfonamide Derivatives TNNI3, TNNT2, TNNC1 ALDH1A1 698/4885KMT2A 1413/4885MAPT 4834/4885
US-20090318509-A1 Oxime Derivatives as Inhibitors of Macrophage Migration Inhibitory Factor MIF, MSR1, MMP12 ALDH1A1 1616/4885KMT2A 3719/4885MAPT 4762/4885
US-20110136827-A1 Bis-Acylated Hydroxylamine Derivatives CPT1A, TNNI3, NOS2 ALDH1A1 198/4885KMT2A 580/4885MAPT 4397/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.