Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.50 |
| ▸ | NOS2 | P35228 | 3/20 | 0.50 |
| ▸ | IDH1 | O75874 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12549325 | 0.92 | NOS3 (0.43) | NOS3NOS2IDH1NOS1ALDH1A1 | |
| SCHEMBL1949112 | 0.85 | NOS3 (0.53) | NOS3NOS2IDH1NOS1ALDH1A1 | |
| SCHEMBL8345724 | 0.79 | NOS3 (0.59) | NOS3NOS2IDH1NOS1ALDH1A1 | |
| SCHEMBL12963699 | 0.76 | NOS3 (0.55) | NOS3NOS2IDH1NOS1ALDH1A1 | |
| SCHEMBL2831934 | 0.74 | NOS2 (0.48) | NOS3NOS2IDH1ALDH1A1CHRNB2 | |
| SCHEMBL9313985 | 0.73 | TLR8 (0.65) | NOS3NOS2ALDH1A1TP53MAPK1 | |
| SCHEMBL24672584 | 0.71 | TLR8 (0.58) | NOS3NOS2ALDH1A1TP53MAPK1 | |
| SCHEMBL11454904 | 0.70 | NOS3 (0.53) | NOS3NOS2IDH1NOS1ALDH1A1 | |
| SCHEMBL23482212 | 0.70 | GAA (0.56) | NOS3NOS2ALDH1A1TP53MAPK1 | |
| SCHEMBL12933368 | 0.70 | NOS3 (0.53) | NOS3NOS2IDH1NOS1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139463-B1 | ANTI-INFECTIVE AGENTS | TECH UNIVERSITÄT CAROLO WILHELMINA ZU BRAUNSCHWEIG (DE) | 2014-08-20 | — | — | EP | disclosed |
| US-8735416-B2 | Antiviral therapies | TECHNISCHE UNIVERSITAET CAROLO-WILHELMINA ZU BRAUNSCHWEIG (DE) | 2014-05-27 | — | — | US | disclosed |
| US-20140113923-A1 | NOVEL ANTIVIRAL THERAPIES | TECHNISCHE UNIVERSITAET CAROLO-WILHELMINA ZU BRAUNSCHWEIG (DE) | 2014-04-24 | — | — | US | disclosed |
| US-8450318-B2 | Method to treat infections using anti-infective agents | K.U. LEUVEN RESEARCH AND DEVELOPMENT (BE) | 2013-05-28 | — | — | US | disclosed |
| US-8450318-B2 | Method to treat infections using anti-infective agents | K.U. LEUVEN RESEARCH AND DEVELOPMENT (BE) | 2013-05-28 | — | — | US | disclosed |
| US-20110136840-A1 | ANTI-INFECTIVE AGENTS | MAZIK, MONIKA (DE) | 2011-06-09 | — | — | US | disclosed |
| US-20110136840-A1 | ANTI-INFECTIVE AGENTS | MAZIK, MONIKA (DE) | 2011-06-09 | — | — | US | disclosed |
| EP-2139463-A2 | ANTI-INFECTIVE AGENTS | Technische Universität Carolo-Wilhelmina zu Braunschweig (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008113557-A2 | ANTI-INFECTIVE AGENTS | Technische Universität Carolo Wilhelmina Zu Braunschweig (DE) | 2008-09-25 | — | — | WO | disclosed |
| EP-1972338-A1 | Anti-infective agents | Technische Universität Carolo-Wilhelmina zu Braunschweig (DE) | 2008-09-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136840-A1 | ANTI-INFECTIVE AGENTS | ICAM1, MANBA, ALG1 | NOS3 3763/4885NOS2 4099/4885IDH1 4524/4885 |
| US-20140113923-A1 | NOVEL ANTIVIRAL THERAPIES | HAVCR2, LGALS3BP, LGALS4 | NOS3 3892/4885NOS2 4319/4885IDH1 2893/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.