SCHEMBL19506431

SCHEMBL19506431

C=C/C=C(\C=C)NC(=O)C(=O)Nc1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TGM2 P21980 2/20 0.51
▸ NPC1 O15118 5/20 0.42
▸ RAB9A P51151 5/20 0.42
▸ PKM P14618 2/20 0.42
▸ SMN1; SMN2 Q16637 6/20 0.41
▸ KMT2A Q03164 4/20 0.41
▸ LMNA P02545 4/20 0.41
▸ MEN1 O00255 3/20 0.41
▸ KDM4E B2RXH2 2/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ MAPT P10636 2/20 0.41
▸ HPGD P15428 2/20 0.41
▸ HTT P42858 2/20 0.41
▸ HDAC3 O15379 1/20 0.41
▸ HDAC4 P56524 1/20 0.41
▸ HDAC1 Q13547 1/20 0.41
▸ HDAC7 Q8WUI4 1/20 0.41
▸ HDAC2 Q92769 1/20 0.41
▸ HDAC10 Q969S8 1/20 0.41
▸ HDAC11 Q96DB2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18661300 0.86 TGM2 (0.44) TGM2NPC1RAB9APKMSMN1; SMN2
SCHEMBL20433894 0.85 TGM2 (0.53) TGM2NPC1RAB9APKMSMN1; SMN2
SCHEMBL23982850 0.85 TGM2 (0.53) TGM2NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL18383509 0.81 TGM2 (0.53) TGM2NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL25496380 0.79 HDAC2 (0.48) TGM2NPC1RAB9AKMT2AMEN1
SCHEMBL20404365 0.77 TGM2 (0.44) TGM2NPC1RAB9APKMSMN1; SMN2
SCHEMBL19501014 0.75 TGM2 (0.49) TGM2NPC1RAB9ASMN1; SMN2KMT2A
SCHEMBL18949934 0.75 CASP3 (0.48) TGM2SMN1; SMN2KMT2AMEN1ALDH1A1
SCHEMBL57554 0.74 SMN1; SMN2 (0.70) TGM2NPC1RAB9APKMSMN1; SMN2
Benzene SCHEMBL28977956 0.74 SMN1; SMN2 (0.70) TGM2NPC1RAB9APKMSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2021-11-11 — — US disclosed
US-20200360264-A1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT L'OREAL (FR) 2020-11-19 — — US disclosed
US-20200030200-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER L'OREAL (FR) 2020-01-30 — — US disclosed
US-20170326045-A1 COSMETIC COMPOSITION COMPRISING A SYNTHETIC PHYLLOSILICATE AND A POLYOL AND/OR A UV FILTER L'OREAL (FR) 2017-11-16 — — US disclosed
US-20170304658-A1 GEL/GEL COMPOSITION COMPRISING A UV-SCREENING AGENT L'OREAL (FR) 2017-10-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200360264-A1 COMPOSITIONS COMPRISING AT LEAST ONE ACRYLIC POLYMER AND AT LEAST ONE INSOLUBLE ORGANIC SCREENING AGENT PCNA, ERCC1, XRCC6 TGM2 1610/4885NPC1 1496/4885RAB9A 3199/4885
US-20170326045-A1 COSMETIC COMPOSITION COMPRISING A SYNTHETIC PHYLLOSILICATE AND A POLYOL AND/OR A UV FILTER PUF60, POLR1C, DPM1 TGM2 1877/4885NPC1 4091/4885RAB9A 3333/4885
US-20200030200-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 TGM2 3448/4885NPC1 3005/4885RAB9A 3649/4885
US-20170304658-A1 GEL/GEL COMPOSITION COMPRISING A UV-SCREENING AGENT CUTA, KRT18, APOL1 TGM2 1238/4885NPC1 1315/4885RAB9A 4315/4885
US-20210346249-A1 COMPOSITION COMPRISING A UV-SCREENING AGENT, AN ANIONIC CROSSLINKED HYDROPHILIC POLYMER, A SURFACTANT HAVING AN HLB LESS THAN OR EQUAL TO 5 AND A SILICONE COPOLYMER ERCC5, CUTA, PLIN5 TGM2 3448/4885NPC1 3005/4885RAB9A 3649/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback