Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950775 | 1.00 | TDP1 (0.48) | TDP1LMNATP53KMT2AMEN1 | |
| SCHEMBL10669991 | 0.93 | LMNA (0.43) | TDP1LMNATP53KMT2AMEN1 | |
| SCHEMBL10669986 | 0.93 | LMNA (0.43) | TDP1LMNATP53KMT2AMEN1 | |
| SCHEMBL23441778 | 0.93 | RECQL (0.44) | TDP1LMNATP53KMT2AMEN1 | |
| SCHEMBL9829322 | 0.91 | NAAA (0.45) | TDP1LMNAKMT2AMEN1 | |
| SCHEMBL9829324 | 0.91 | NAAA (0.45) | TDP1LMNAKMT2AMEN1 | |
| SCHEMBL1951843 | 0.89 | TP53 (0.50) | TDP1LMNATP53KMT2AMEN1 | |
| SCHEMBL1951845 | 0.89 | TP53 (0.50) | TDP1LMNATP53KMT2AMEN1 | |
| SCHEMBL25046028 | 0.89 | TP53 (0.50) | TDP1LMNATP53KMT2AMEN1 | |
| SCHEMBL12630399 | 0.85 | TP53 (0.39) | TDP1LMNATP53KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2507232-B1 | PROLINE DERIVATIVES | NATIONAL HEALTH RES INST (TW) | 2019-03-20 | — | — | EP | disclosed |
| CN-102482269-B | Proline derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (CN) | 2015-07-29 | — | — | CN | disclosed |
| US-8415482-B2 | Proline derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2013-04-09 | — | — | US | disclosed |
| CN-102482269-A | Proline derivatives | NAT HEALTH RESEARCH INSTITUTES | 2012-05-30 | — | — | CN | disclosed |
| US-20110136799-A1 | PROLINE DERIVATIVES | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136799-A1 | PROLINE DERIVATIVES | PNISR, ARGLU1, PRR12 | TDP1 2741/4885LMNA 2863/4885TP53 1280/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.