Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18685613 | 0.80 | KMT2A (0.46) | KMT2AMEN1ALDH1A1MAPTRECQL | |
| SCHEMBL18000168 | 0.74 | KMT2A (0.53) | HTR6LDHAKMT2AGRM2HSD11B1 | |
| SCHEMBL29509074 | 0.73 | GRM2 (0.42) | HTR6LDHAKMT2AGRM2HSD11B1 | |
| SCHEMBL17504839 | 0.73 | GRM2 (0.42) | HTR6LDHAKMT2AGRM2HSD11B1 | |
| SCHEMBL19559091 | 0.69 | RAPGEF4 (0.37) | ALDH1A1MAPTNPC1RAB9A | |
| SCHEMBL20739962 | 0.68 | MAPT (0.42) | KMT2ACYP19A1MEN1ALDH1A1MAPT | |
| SCHEMBL31743093 | 0.68 | BRPF1 (0.59) | HTR6LDHAKMT2AGRM2HSD11B1 | |
| SCHEMBL19559022 | 0.67 | KMT2A (0.46) | KMT2AMEN1ALDH1A1MAPTRECQL | |
| SCHEMBL11524631 | 0.67 | KMT2A (0.58) | LDHAKMT2AGRM2HSD11B1SLC2A1 | |
| SCHEMBL23638931 | 0.66 | TRPA1 (0.60) | ALDH1A1MAPTNPC1RAB9ANR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2023-09-12 | — | — | US | disclosed |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2022-06-16 | — | — | US | disclosed |
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2022-04-26 | — | — | US | disclosed |
| US-20210047348-A1 | Silylated Derivatives Of Aromatic Heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2021-02-18 | — | — | US | disclosed |
| US-10919917-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-02-16 | — | — | US | disclosed |
| US-10513531-B2 | Silylated derivatives of aromatic heterocycles | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2019-12-24 | — | — | US | disclosed |
| US-20190048030-A1 | SILYLATED DERIVATIVES OF AROMATIC HETEROCYCLES | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-02-14 | — | — | US | disclosed |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2018-03-01 | — | — | US | disclosed |
| US-9809607-B2 | Silylation of aromatic heterocycles by earth abundant transition-metal-free catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11312733-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | HTR6 1808/4885LDHA 1178/4885KMT2A 654/4885 |
| US-20180057514-A1 | SILYLATION OF AROMATIC HETEROCYCLES BY EARTH ABUNDANT TRANSITION-METAL-FREE CATALYSTS | TEC, AURKA, TYR | HTR6 4202/4885LDHA 1070/4885KMT2A 384/4885 |
| US-11753421-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | HTR6 1808/4885LDHA 1178/4885KMT2A 654/4885 |
| US-10919917-B2 | Silylated derivatives of aromatic heterocycles | KCNH1, KCNH3, HNRNPH3 | HTR6 1563/4885LDHA 961/4885KMT2A 566/4885 |
| US-20210047348-A1 | Silylated Derivatives Of Aromatic Heterocycles | KCNH1, KCNH3, HNRNPH3 | HTR6 1808/4885LDHA 1178/4885KMT2A 654/4885 |
| US-20220185828-A1 | Silylated Derivatives Of Aromatic Heterocycles | KCNH1, KCNH3, HNRNPH3 | HTR6 1808/4885LDHA 1178/4885KMT2A 654/4885 |
| US-10513531-B2 | Silylated derivatives of aromatic heterocycles | HNRNPH3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SBK3 | HTR6 3074/4885LDHA 718/4885KMT2A 825/4885 |
| US-20190048030-A1 | SILYLATED DERIVATIVES OF AROMATIC HETEROCYCLES | HNRNPH3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, SBK3 | HTR6 3074/4885LDHA 718/4885KMT2A 825/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.