Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.42 |
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12543781 | 0.87 | RAB9A (0.43) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL12543265 | 0.82 | NPC1 (0.46) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL21301102 | 0.76 | L3MBTL1 (0.43) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL6801124 | 0.75 | KMT2A (0.58) | RAB9ANPC1ATMALDH1A1KMT2A | |
| SCHEMBL2888789 | 0.74 | L3MBTL1 (0.47) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL24399168 | 0.74 | LMNA (0.39) | ALDH1A1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL8878002 | 0.73 | L3MBTL1 (0.61) | RAB9ANPC1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL23986656 | 0.73 | ALDH1A1 (0.66) | ALDH1A1KMT2AL3MBTL1MEN1KDM4E | |
| SCHEMBL12543290 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KMT2AL3MBTL1MEN1POLB | |
| SCHEMBL21749211 | 0.72 | L3MBTL1 (0.45) | RAB9ANPC1ATMALDH1A1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513111-A1 | MK2 INHIBITORS | MSD Oss B.V. (NL) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073119-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2011-06-23 | — | — | WO | disclosed |