Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1958682 | 0.87 | RAB9A (0.42) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL24399168 | 0.85 | LMNA (0.39) | ALDH1A1KMT2AL3MBTL1LMNAMAPT | |
| SCHEMBL12543290 | 0.84 | ALDH1A1 (0.44) | ALDH1A1KMT2AL3MBTL1LMNAMAPT | |
| SCHEMBL12543265 | 0.84 | NPC1 (0.46) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL17361120 | 0.81 | HSD11B1 (0.39) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL20987918 | 0.77 | MMP2 (0.35) | RAB9ANPC1ALDH1A1MMP2MMP13 | |
| SCHEMBL21301102 | 0.77 | L3MBTL1 (0.43) | RAB9ANPC1ATMALDH1A1MMP2 | |
| SCHEMBL6801124 | 0.76 | KMT2A (0.58) | RAB9ANPC1ATMALDH1A1KMT2A | |
| SCHEMBL8878002 | 0.74 | L3MBTL1 (0.61) | RAB9ANPC1ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL24399484 | 0.74 | ALDH1A1 (0.42) | ALDH1A1KMT2AL3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160159800-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2016-06-09 | — | — | US | disclosed |
| US-9102676-B2 | MK2 inhibitors | MERCK SHARP & DOHME B.V. (NL) | 2015-08-11 | — | — | US | disclosed |
| US-20140288109-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2014-09-25 | — | — | US | disclosed |
| US-8772286-B2 | MK2 inhibitors | MERCK SHARP & DOHME B.V. (NL) | 2014-07-08 | — | — | US | disclosed |
| EP-2513111-B1 | MK2 INHIBITORS | MERCK SHARP & DOHME (NL) | 2013-10-02 | — | — | EP | disclosed |
| US-20120245175-A1 | MK2 INHIBITORS | N.V. ORGANON (NL) | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140288109-A1 | MK2 INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | RAB9A 1084/4885NPC1 1809/4885ATM 1600/4885 |
| US-20160159800-A1 | MK2 INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | RAB9A 1191/4885NPC1 1761/4885ATM 1587/4885 |
| US-20120245175-A1 | MK2 INHIBITORS | MKNK2, MAPKAPK2, MAP3K2 | RAB9A 1084/4885NPC1 1809/4885ATM 1600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.