SCHEMBL195983

SCHEMBL195983

CCOC(=O)/C=C/C(F)(F)F

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.54
MAPT P10636 5/20 0.44
NPSR1 Q6W5P4 1/20 0.42
CA12 O43570 1/20 0.42
CA1 P00915 1/20 0.42
CA2 P00918 1/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
ALDH1A1 P00352 3/20 0.40
ATM Q13315 1/20 0.39
TTR P02766 1/20 0.39
DPP4 P27487 1/20 0.39
LMNA P02545 2/20 0.37
HSD17B10 Q99714 1/20 0.37
MDM2 Q00987 1/20 0.37
CYP3A4 P08684 1/20 0.37
MLYCD O95822 1/20 0.36
ALOX15 P16050 1/20 0.36
MGAM O43451 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL863510 1.00 HCAR2 (0.54) HCAR2MAPTNPSR1CA12CA1
SCHEMBL195984 1.00 HCAR2 (0.54) HCAR2MAPTNPSR1CA12CA1
SCHEMBL23666175 0.87 HCAR2 (0.54) HCAR2MAPTNPSR1CA12CA1
SCHEMBL17285584 0.85 HCAR2 (0.52) HCAR2MAPTNPSR1CA12CA1
SCHEMBL29740078 0.83 HCAR2 (0.43) HCAR2MAPTNPSR1CA12CA1
SCHEMBL2969893 0.83 HCAR2 (0.50) HCAR2MAPTNPSR1CA12CA1
SCHEMBL22231629 0.83 HCAR2 (0.57) HCAR2MAPTNPSR1ALDH1A1ATM
SCHEMBL22231627 0.83 HCAR2 (0.57) HCAR2MAPTNPSR1ALDH1A1ATM
SCHEMBL2969895 0.83 HCAR2 (0.50) HCAR2MAPTNPSR1CA12CA1
SCHEMBL25729806 0.83 HCAR2 (0.50) HCAR2MAPTNPSR1CA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 534 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111138596-B Polymer electrolyte and lithium ion battery comprising same 珠海冠宇电池股份有限公司 2022-09-30 CN claimed
CN-112824437-A Preparation method of modified polyaramide and modified polyaramide 欧美新材料(浙江)有限公司 2021-05-21 CN claimed
US-10414744-B2 4-sulfur pentafluoride phenol compound and preparation method therefor, and preparation method for sulfur pentafluoride substituted benzopyran compound Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences (CN) 2019-09-17 US claimed
US-20190084957-A1 4-SULFUR PENTAFLUORIDE PHENOL COMPOUND AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR SULFUR PENTAFLUORIDE SUBSTITUTED BENZOPYRAN COMPOUND Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences (CN) 2019-03-21 US claimed
EP-3428154-A1 4-SULFUR PENTAFLUORIDE PHENOL COMPOUND AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR SULFUR PENTAFLUORIDE SUBSTITUTED BENZOPYRAN COMPOUND Guangzhou Institutes Of Biomedicine And Health Chinese Academy Of Sciences (CN) 2019-01-16 EP claimed
EP-1044991-B1 Process of preparing curable compositions and compositions therefrom ROHM & HAAS (US) 2004-02-11 EP claimed
US-20020137857-A1 Forming an oligomer containing reactive functional groups,and reacting a modifier that also contains reactive function groups with the oligomer ROHM AND HAAS COMPANY 2002-09-26 US claimed
EP-1044991-A1 Process of preparing curable compositions and compositions therefrom ROHM AND HAAS COMPANY (US) 2000-10-18 EP claimed
US-12544356-B2 Combination of a chromene compound and a second active agent Euclises Pharmaceuticals, Inc. (US) 2026-02-10 US disclosed
US-20260034094-A1 COMPOSITIONS AND METHODS FOR INDUCING FERROPTOSIS KOJIN THERAPEUTICS INC (US) 2026-02-05 US disclosed
EP-4656201-A2 RAS INHIBITORS Revolution Medicines, Inc. (US) 2025-12-03 EP disclosed
US-20250304567-A1 PYRROLIDIONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE JANSSEN PHARMACEUTICA NV (BE) 2025-10-02 US disclosed
US-20250296910-A1 BENZAMIDE ENAMINONE DERIVATIVES AND METHODS OF USE THEREOF UNIVERSITY OF MARYLAND EASTERN SHORE 2025-09-25 US disclosed
US-20250282768-A1 PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE JANSSEN PHARMACEUTICA NV (BE) 2025-09-11 US disclosed
US-4404203-A AND 6-PHENYL-4,5-DIHYDRO-3/2H/-PYRIDAZINONES WARNER-LAMBERT COMPANY (US) 1983-09-13 US disclosed
US-4325877-A Production of intermediates for enzyme inhibitors RICHARDSON-MERRELL INC. (US) 1982-04-20 US disclosed
US-4277395-A OF ELASTASE; OLIGOPEPTIDES RICHARDSON-MERRELL INC. (US) 1981-07-07 US disclosed
EP-0021883-A2 N-acyl-amino acid derivatives and pharmaceutical compositions containing them, intermediates and starting compounds MERRELL TORAUDE ET COMPAGNIE (FR) 1981-01-07 EP disclosed
US-4241076-A HYPOTENSIVE AGENTS E. R. SQUIBB & SONS, INC. (US) 1980-12-23 US disclosed
US-4154935-A Halogen substituted mercaptoacylamino acids E. R. SQUIBB & SONS, INC. (US) 1979-05-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250304567-A1 PYRROLIDIONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE NFKBIA, IKBKG, IKBKB HCAR2 3142/4885MAPT 3238/4885NPSR1 4130/4885
US-20250282768-A1 PYRROLIDINONE DERIVATIVES AS INHIBITORS OF NF KAPPA B INDUCING KINASE NFKBIA, IKBKG, IKBKB HCAR2 2775/4885MAPT 3296/4885NPSR1 4080/4885
US-12544356-B2 Combination of a chromene compound and a second active agent CD274, ICOS, PDCD1 HCAR2 1333/4885MAPT 2317/4885NPSR1 938/4885
US-20190084957-A1 4-SULFUR PENTAFLUORIDE PHENOL COMPOUND AND PREPARATION METHOD THEREFOR, AND PREPARATION METHOD FOR SULFUR PENTAFLUORIDE SUBSTITUTED BENZOPYRAN COMPOUND SALL4, FGFR4, CYP4F11 HCAR2 2740/4885MAPT 3811/4885NPSR1 1583/4885
US-20250296910-A1 BENZAMIDE ENAMINONE DERIVATIVES AND METHODS OF USE THEREOF GABBR2, GABBR1, GABRA5 HCAR2 651/4885MAPT 2166/4885NPSR1 1489/4885
US-20260034094-A1 COMPOSITIONS AND METHODS FOR INDUCING FERROPTOSIS AIFM2, GPX4, HMOX1 HCAR2 837/4885MAPT 4831/4885NPSR1 3484/4885
US-10414744-B2 4-sulfur pentafluoride phenol compound and preparation method therefor, and preparation method for sulfur pentafluoride substituted benzopyran compound SALL4, FGFR4, CYP4F11 HCAR2 2740/4885MAPT 3811/4885NPSR1 1583/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.