Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 5/20 | 0.47 |
| ▸ | HCRTR2 | O43614 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17859344 | 0.83 | LMNA (0.60) | ABCB1KDM4EHCRTR1HCRTR2KMT2A | |
| SCHEMBL10451670 | 0.83 | KDM4E (0.49) | KDM4EHCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL1434118 | 0.81 | ALDH1A1 (0.59) | KDM4EMEN1USP2TSHRKMT2A | |
| SCHEMBL3029800 | 0.81 | HCRTR1 (0.62) | ABCB1KDM4EHCRTR1MEN1USP2 | |
| SCHEMBL29601648 | 0.81 | ALDH1A1 (0.47) | KDM4EHCRTR1HCRTR2MEN1KMT2A | |
| SCHEMBL10499645 | 0.81 | SLC6A3 (0.54) | KDM4EMEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL19599253 | 0.81 | UGCG (0.48) | KDM4EHCRTR1HCRTR2ALDH1A1MRGPRX1 | |
| SCHEMBL2776834 | 0.80 | ABCB1 (0.47) | ABCB1KDM4EHCRTR1MEN1USP2 | |
| SCHEMBL11784830 | 0.80 | ALDH1A1 (0.57) | KDM4EMEN1USP2TSHRKMT2A | |
| SCHEMBL13780116 | 0.80 | F2R (0.50) | ABCB1KDM4EHCRTR1HCRTR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170327490-A1 | PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327490-A1 | PIPERIDINE ISOXAZOLE AND ISOTHIAZOLE OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, OXTR | ABCB1 2046/4885KDM4E 2136/4885HCRTR1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.