Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TYR | P14679 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12012867 | 0.75 | SMN1; SMN2 (0.40) | CDK1ALDH1A1L3MBTL1KMT2AMAPT | |
| SCHEMBL6138207 | 0.75 | GAA (0.48) | CDK1ALDH1A1KMT2ATDP1MAPT | |
| SCHEMBL19621198 | 0.73 | SKP2 (0.44) | CDK1ALDH1A1MAPTHSD17B10SMN1; SMN2 | |
| SCHEMBL19240330 | 0.73 | ALDH1A1 (0.42) | ALDH1A1KMT2ATDP1MAPTKDM4E | |
| SCHEMBL19251029 | 0.71 | NPC1 (0.37) | ALDH1A1GAAHSD17B10SMN1; SMN2 | |
| SCHEMBL7935368 | 0.70 | MAOA (0.51) | CDK1ALDH1A1TDP1MAPTKDM4E | |
| SCHEMBL19604353 | 0.70 | ESRRB (0.39) | ALDH1A1L3MBTL1MAPTHPGDKDM4E | |
| SCHEMBL648537 | 0.70 | AGXT (0.39) | TSHR | |
| SCHEMBL11957416 | 0.69 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1TDP1MAPTHPGD | |
| SCHEMBL13638852 | 0.69 | HRH3 (0.44) | ALDH1A1L3MBTL1KMT2ATDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170326250-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2017-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170326250-A1 | CELL PROLIFERATION INHIBITORS AND CONJUGATES THEREOF | MKI67, CCNI, PA2G4 | CDK1 34/4885ALDH1A1 2251/4885L3MBTL1 3571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.