Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.44 |
| ▸ | RAB9A | P51151 | 8/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 3/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.37 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.37 |
| ▸ | CLK1 | P49759 | 2/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PRKCB | P05771 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3032150 | 0.82 | NPC1 (0.49) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL3013600 | 0.76 | NPC1 (0.44) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL1799071 | 0.74 | KDM4E (0.49) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL3396673 | 0.74 | NPC1 (0.53) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL266440 | 0.70 | RAB9A (0.54) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL29870814 | 0.70 | RAB9A (0.54) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL26790748 | 0.69 | ALDH1A1 (0.45) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL13217643 | 0.69 | GRM5 (0.55) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL13217766 | 0.69 | NPC1 (0.50) | NPC1RAB9AL3MBTL1KDM4ETDP1 | |
| SCHEMBL20625687 | 0.68 | TGFBR1 (0.47) | NPC1RAB9AL3MBTL1KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190315731-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS, LTD. (CH) | 2019-10-17 | — | — | US | disclosed |
| US-20190315731-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | ACTELION PHARMACEUTICALS, LTD. (CH) | 2019-10-17 | — | — | US | disclosed |
| EP-3458453-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | Idorsia Pharmaceuticals Ltd (CH) | 2019-03-27 | — | — | EP | disclosed |
| WO-2017198647-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315731-A1 | 6-(BUTA-1,3-DIYN-1-YL)BENZO[D]THIAZOLE DERIVATIVES | TMBIM6, BTN3A1, BET1 | NPC1 790/4885RAB9A 1760/4885L3MBTL1 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.