Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.90 |
| ▸ | LMNA | P02545 | 1/20 | 0.86 |
| ▸ | TSHR | P16473 | 2/20 | 0.83 |
| ▸ | MEN1 | O00255 | 2/20 | 0.83 |
| ▸ | GJA1 | P17302 | 1/20 | 0.83 |
| ▸ | GJB2 | P29033 | 1/20 | 0.83 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.83 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.83 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.78 |
| ▸ | LRAT | O95237 | 2/20 | 0.76 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | BLM | P54132 | 1/20 | 0.70 |
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13873408 | 1.00 | ALOX15 (0.90) | ALOX15KDM4ELMNATSHRMEN1 | |
| SCHEMBL12167988 | 1.00 | ALOX15 (0.90) | ALOX15KDM4ELMNATSHRMEN1 | |
| SCHEMBL16882178 | 1.00 | ALOX15 (0.90) | ALOX15KDM4ELMNATSHRMEN1 | |
| SCHEMBL17917312 | 1.00 | ALOX15 (0.90) | ALOX15KDM4ELMNATSHRMEN1 | |
| SCHEMBL29885177 | 0.99 | ALOX15 (0.88) | ALOX15KDM4ELMNATSHRMEN1 | |
| Bekanamycin SCHEMBL23879718 | 0.95 | ALOX15 (1.00) | ALOX15KDM4ELMNATSHRMEN1 | |
| Bekanamycin SCHEMBL9250504 | 0.95 | ALOX15 (1.00) | ALOX15KDM4ELMNATSHRMEN1 | |
| Bekanamycin SCHEMBL12553422 | 0.95 | ALOX15 (1.00) | ALOX15KDM4ELMNATSHRMEN1 | |
| Bekanamycin SCHEMBL14944403 | 0.95 | ALOX15 (1.00) | ALOX15KDM4ELMNATSHRMEN1 | |
| Bekanamycin SCHEMBL17265214 | 0.95 | ALOX15 (1.00) | ALOX15KDM4ELMNATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11613551-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | ELOXX PHARMACEUTICALS LTD. (IL) | 2023-03-28 | — | — | US | disclosed |
| US-20210300958-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2021-09-30 | — | — | US | disclosed |
| US-20190016746-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | ELOXX PHARMACEUTICALS LTD. (IL) | 2019-01-17 | — | — | US | disclosed |
| US-20180064743-A1 | NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2018-03-08 | — | — | US | disclosed |
| US-9821001-B2 | Aminoglycosides and uses thereof in the treatment of genetic disorders | TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED (IL) | 2017-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180064743-A1 | NOVEL AMINOGLYCOSIDES AND USES THEREOF IN THE TREATMENT OF GENETIC DISORDERS | AARS1, NARS1, GOT1 | ALOX15 3724/4885KDM4E 3943/4885LMNA 1943/4885 |
| US-20210300958-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | UPF1, AARS1, NUDT21 | ALOX15 4417/4885KDM4E 2974/4885LMNA 1286/4885 |
| US-20190016746-A1 | AMINOGLYCOSIDE DERIVATIVES AND USES THEREOF IN TREATING GENETIC DISORDERS | UPF1, AARS1, GET3 | ALOX15 4603/4885KDM4E 2925/4885LMNA 1125/4885 |
| US-11613551-B2 | Aminoglycoside derivatives and uses thereof in treating genetic disorders | UPF1, AARS1, NUDT21 | ALOX15 4417/4885KDM4E 2974/4885LMNA 1286/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.