Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 8/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.38 |
| ▸ | FXR2 | P51116 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19620278 | 0.88 | NR1H4 (0.42) | NR1H4MRGPRX4RORC | |
| SCHEMBL19230512 | 0.83 | NR1H4 (0.37) | NR1H4MRGPRX4FXR2 | |
| SCHEMBL23773955 | 0.82 | RARA (0.36) | NR1H4MRGPRX4 | |
| SCHEMBL19230320 | 0.78 | FAAH (0.38) | TAS1R3TAS1R1 | |
| SCHEMBL19620271 | 0.78 | NR1H4 (0.43) | NR1H4MRGPRX4 | |
| SCHEMBL19202366 | 0.78 | NR1H4 (0.31) | NR1H4 | |
| SCHEMBL20094741 | 0.77 | OPRD1 (0.35) | NR1H4MRGPRX4PLA2G4B | |
| SCHEMBL19230756 | 0.76 | ITGB3 (0.38) | NR1H4MRGPRX4FXR2 | |
| SCHEMBL16230399 | 0.75 | NR1H4 (0.56) | NR1H4FXR2 | |
| SCHEMBL23773941 | 0.75 | NR4A2 (0.38) | NR1H4MRGPRX4PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246070-A1 | NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING AZOLES | Gilead Sciences, Inc. (US) | 2017-11-22 | — | — | EP | disclosed |