Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.50 |
| ▸ | CDC25B | P30305 | 4/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 4/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AGER | Q15109 | 4/20 | 0.43 |
| ▸ | HEXA | P06865 | 1/20 | 0.40 |
| ▸ | HEXB | P07686 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19626751 | 0.87 | PTGDR2 (0.66) | HTTPTGDR2GAAALDH1A1PTPN1 | |
| SCHEMBL28931361 | 0.84 | HTT (0.70) | HTTPTGDR2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL19626591 | 0.83 | PTGDR2 (0.58) | HTTPTGDR2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL19625496 | 0.80 | HTT (0.65) | HTTPTGDR2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL19626585 | 0.79 | PTGDR2 (0.61) | HTTPTGDR2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL791528 | 0.79 | PTGDR2 (0.61) | HTTPTGDR2GAAALDH1A1PTGS1 | |
| SCHEMBL5820072 | 0.77 | PTGDR2 (1.00) | PTGDR2GAAALDH1A1MEN1KMT2A | |
| SCHEMBL19626744 | 0.76 | PTGDR2 (0.53) | HTTPTGDR2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL2090659 | 0.75 | ALDH1A1 (0.61) | HTTPTGDR2GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL4065987 | 0.73 | GPR84 (0.51) | PTGDR2GAAALDH1A1SMN1; SMN2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334912-A1 | Purine Diones As Wnt Pathway Modulators | WNT1, WNT3A, CTNNB1 | HTT 3968/4885PTGDR2 443/4885GAA 4553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.