Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 8/20 | 0.36 |
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15577021 | 0.93 | NOS3 (0.37) | SLC6A4HTR1ASLC6A2SLC6A3CHRNB2 | |
| SCHEMBL18790124 | 0.78 | HTR2C (0.46) | OPRL1HTR2CPDK2PDK4HTR6 | |
| SCHEMBL15577034 | 0.78 | ADRA2A (0.35) | HTR1ASLC6A2HTR2CPDK2PDK4 | |
| SCHEMBL10192326 | 0.76 | NOS3 (0.34) | SLC6A4HTR1ASLC6A2SLC6A3CHRNB2 | |
| SCHEMBL10245295 | 0.76 | ALOX5AP (0.34) | SLC6A4HTR1ASLC6A2SLC6A3CHRNB2 | |
| SCHEMBL807556 | 0.76 | CES2 (0.41) | SLC6A2HTR2C | |
| SCHEMBL25464013 | 0.74 | HTR2C (0.49) | SLC6A4HTR1ASLC6A2SLC6A3DRD2 | |
| SCHEMBL17988482 | 0.74 | GLP1R (0.36) | OPRL1TLR9TLR8TLR7 | |
| SCHEMBL25464003 | 0.74 | SLC6A4 (0.37) | SLC6A4SLC6A2SLC6A3DRD2HTR2C | |
| SCHEMBL19633961 | 0.74 | HTR2C (0.48) | SLC6A4HTR1ASLC6A2SLC6A3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170334893-A1 | Isoxazole Analogs as FXR Agonists and Methods of Use Thereof | ENANTA PHARMACEUTICALS, INC. | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170334893-A1 | Isoxazole Analogs as FXR Agonists and Methods of Use Thereof | FXR1, SLC10A1, NR1H4 | SLC6A4 962/4885HTR1A 1692/4885SLC6A2 1290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.