Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9734348 | 0.78 | GABRA1 (0.50) | GABRA1GABRB2PDK2LMNASMN1; SMN2 | |
| SCHEMBL23487737 | 0.78 | NOTUM (0.40) | SLC6A4SLC6A2SLC6A3GABRA1GABRB2 | |
| SCHEMBL7135459 | 0.77 | HCRTR2 (0.45) | SLC6A4SLC6A2SLC6A3GABRA1GABRB2 | |
| SCHEMBL18790124 | 0.76 | HTR2C (0.46) | PDK2PDK4MEN1KMT2AHTR2C | |
| SCHEMBL21163634 | 0.76 | HTR2C (0.46) | GABRA1GABRB2PDK2PDK4MEN1 | |
| SCHEMBL19628517 | 0.74 | SLC6A4 (0.36) | SLC6A4SLC6A2SLC6A3PDK2PDK4 | |
| SCHEMBL2047127 | 0.74 | GABRA1 (0.59) | SLC6A4SLC6A2SLC6A3GABRA1GABRB2 | |
| SCHEMBL23664862 | 0.72 | HSD11B1 (0.37) | PDK2PDK4LMNAHTR6 | |
| SCHEMBL25464013 | 0.71 | HTR2C (0.49) | SLC6A4SLC6A2SLC6A3MEN1KMT2A | |
| SCHEMBL15577034 | 0.71 | ADRA2A (0.35) | SLC6A2GABRA1GABRB2PDK2PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023083297-A1 | SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF | INSILICO MEDICINE IP LIMITED (CN) | 2023-05-19 | — | — | WO | disclosed |