Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19632895 | 0.91 | MAPT (0.39) | ALDH1A1BACE1KCNH2TSHRKMT2A | |
| SCHEMBL19632855 | 0.88 | BACE1 (0.44) | ALDH1A1BACE1TSHRKMT2AOPRM1 | |
| SCHEMBL19617143 | 0.79 | KCNH2 (0.38) | ALDH1A1KCNH2OPRM1OPRD1OPRK1 | |
| SCHEMBL8550616 | 0.70 | OPRM1 (0.43) | KCNH2OPRM1OPRD1OPRK1GAA | |
| SCHEMBL10573881 | 0.67 | ALDH1A1 (0.40) | ALDH1A1BACE1KCNH2PKM | |
| SCHEMBL8845508 | 0.65 | MAOB (0.45) | KCNH2 | |
| SCHEMBL10688570 | 0.65 | OPRK1 (0.52) | ALDH1A1BACE1BRD4TSHRKMT2A | |
| SCHEMBL14497610 | 0.64 | KCNH2 (0.61) | ALDH1A1BACE1KCNH2PKMTSHR | |
| SCHEMBL6561883 | 0.64 | KCNH2 (0.61) | ALDH1A1BACE1KCNH2PKMTSHR | |
| SCHEMBL14497609 | 0.64 | KCNH2 (0.61) | ALDH1A1BACE1KCNH2PKMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458439-B1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | ALERE SAN DIEGO INC (US) | 2021-12-08 | — | — | EP | disclosed |
| US-11192857-B2 | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use | ALERE SAN DIEGO, INC. (US) | 2021-12-07 | — | — | US | disclosed |
| US-20190292148-A1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | ALERE SAN DIEGO, INC. (US) | 2019-09-26 | — | — | US | disclosed |
| WO-2017201314-A1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | ALERE SAN DIEGO, INC. (US) | 2017-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11192857-B2 | 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine analogs and methods for their synthesis and use | DPYSL2, DNPEP, DPYSL3 | ALDH1A1 3397/4885BACE1 3051/4885KCNH2 4297/4885 |
| US-20190292148-A1 | 2-ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDINE ANALOGS AND METHODS FOR THEIR SYNTHESIS AND USE | DPYSL2, DNPEP, DPYSL3 | ALDH1A1 3397/4885BACE1 3051/4885KCNH2 4297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.