Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.53 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.53 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.48 |
| ▸ | TUBB | P07437 | 1/20 | 0.48 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.48 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.48 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.48 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.48 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.48 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.48 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.48 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633688 | 0.86 | KDR (0.52) | KDRAURKAMETTEKAURKB | |
| SCHEMBL19633698 | 0.86 | TUBB1 (0.57) | GAKRIPK2COQ8ANLKMET | |
| SCHEMBL19633713 | 0.82 | GAK (0.49) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL19633780 | 0.82 | GAK (0.71) | GAKRIPK2COQ8ANLKEGFR | |
| SCHEMBL19633706 | 0.81 | PDGFRA (0.57) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL19633753 | 0.81 | GAK (0.49) | GAKRIPK2COQ8ANLKKDR | |
| SCHEMBL19633749 | 0.79 | TUBB1 (0.54) | GAKRIPK2COQ8ANLKEGFR | |
| SCHEMBL19633779 | 0.79 | TUBB1 (0.65) | GAKRIPK2COQ8ANLKEGFR | |
| SCHEMBL19968424 | 0.77 | CYP3A4 (0.57) | METPDGFRAPDGFRB | |
| SCHEMBL25466495 | 0.77 | FGFR2 (0.60) | KDRAURKAMETTEKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017198196-A1 | QUINOLINE DERIVATIVE HAVING ANTI-TUMOR ACTIVITY | 王子厚 | 2017-11-23 | — | — | WO | disclosed |