Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | SCN1A | P35498 | 2/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.39 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634256 | 0.93 | P2RX3 (0.37) | PDE4BPDE4APDE4CPDE4DSCN1A | |
| SCHEMBL19634031 | 0.91 | STS (0.36) | PDE4BSCN1ASCN8ASTSMEN1 | |
| SCHEMBL19634114 | 0.90 | SCN1A (0.37) | PDE4BPDE4APDE4CPDE4DSCN1A | |
| SCHEMBL19634139 | 0.89 | MAPT (0.39) | PDE4BPDE4APDE4CPDE4DSCN1A | |
| SCHEMBL19634096 | 0.86 | MAPT (0.39) | PDE4BPDE4APDE4CPDE4DSTS | |
| SCHEMBL19634176 | 0.85 | P2RX3 (0.36) | STSMEN1KMT2AMAPTEPHX2 | |
| SCHEMBL19613659 | 0.85 | SCN8A (0.46) | PDE4BPDE4APDE4CPDE4DSCN1A | |
| SCHEMBL19634261 | 0.83 | MAPT (0.39) | PDE4BPDE4APDE4CPDE4DSCN1A | |
| SCHEMBL22590192 | 0.81 | GPR119 (0.44) | PDE4BPDE4APDE4CPDE4DSCN1A | |
| SCHEMBL19633926 | 0.80 | STS (0.36) | PDE4BPDE4APDE4CPDE4DSCN1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017201468-A1 | BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2017-11-23 | — | — | WO | disclosed |