Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11739223 | 0.98 | HSD11B1 (0.42) | ALDH1A1ALOX15PTGS2HSD11B1HDAC4 | |
| SCHEMBL1965582 | 0.93 | — | — | |
| SCHEMBL11233670 | 0.85 | — | — | |
| SCHEMBL18569622 | 0.83 | ALDH1A1 (0.32) | ALDH1A1ALOX15PTGS2HSD11B1 | |
| SCHEMBL8031497 | 0.82 | HSD11B1 (0.43) | ALDH1A1ALOX15PTGS2HSD11B1HDAC4 | |
| SCHEMBL11148487 | 0.80 | HSD11B1 (0.46) | ALDH1A1ALOX15PTGS2HSD11B1HDAC4 | |
| SCHEMBL329274 | 0.78 | HSD11B1 (0.41) | ALDH1A1ALOX15PTGS2HSD11B1HDAC4 | |
| SCHEMBL11567205 | 0.77 | ALDH1A1 (0.41) | ALDH1A1ALOX15PTGS2HSD11B1HDAC4 | |
| SCHEMBL5576456 | 0.76 | HSD11B1 (0.40) | ALDH1A1ALOX15PTGS2HSD11B1HDAC4 | |
| SCHEMBL11793191 | 0.76 | HSD11B1 (0.40) | ALDH1A1ALOX15PTGS2HSD11B1HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022135470-A1 | PREPARATION AND APPLICATION METHOD OF HETEROCYCLIC COMPOUND AS KRAS INHIBITOR | 上海科州药物研发有限公司 | 2022-06-30 | — | — | WO | disclosed |
| WO-2020233592-A1 | HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF | INVENTISBIO SHANGHAI LTD. (CN) | 2020-11-26 | — | — | WO | disclosed |
| US-20170129897-A1 | Pyrazolopyrimidine Derivatives Useful as Inhibitors of Bruton's Tyrosine Kinase | LOXO ONCOLOGY, INC. | 2017-05-11 | — | — | US | disclosed |
| US-20110143939-A1 | QUINOXALIN-2-ONE DERIVATIVES, COMPOSITIONS WHICH PROTECT USEFUL PLANTS AND COMPRISE THESE DERIVATIVES, AND PROCESSES FOR THEIR PREPARATION AND THEIR USE | BAYER CROPSCIENCE AG (DE) | 2011-06-16 | — | — | US | disclosed |
| US-7332509-B2 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED (US) | 2008-02-19 | — | — | US | disclosed |
| US-20060173022-A1 | Heterocyclic amides, method for the production thereof, substances containing said heterocyclic amides, and use thereof as pesticides | BAYER CROPSCIENCE GMBH (DE) | 2006-08-03 | — | — | US | disclosed |
| US-20050256000-A1 | Quinoxalin-2-one derivatives, compositions which protect useful plants and comprise these derivatives, and processes for their preparation and their use | BAYER CROPSCIENCE GMBH (DE) | 2005-11-17 | — | — | US | disclosed |
| US-20040006047-A1 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | MERIAL LIMITED | 2004-01-08 | — | — | US | disclosed |
| US-5753715-A | 2-disubstituted cyclohexenyl and cyclohexyl antimicrobial agents | ORTHO PHARMACEUTICAL CORPORATION (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1997048675-A1 | 2-DISUBSTITUTED CYCLOHEXENYL AND CYCLOHEXYL ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-12-24 | — | — | WO | disclosed |
| US-4022804-A | ADDITION REACTION; SULFONIC ACID BROMIDES, UNSATURATED COMPOUNDS | BASF AKTIENGESELLSCHAFT (DT) | 1977-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256000-A1 | Quinoxalin-2-one derivatives, compositions which protect useful plants and comprise these derivatives, and processes for their preparation and their use | QSOX1, CYC1, CBR3 | ALDH1A1 1058/4885ALOX15 456/4885PTGS2 1265/4885 |
| US-20110143939-A1 | QUINOXALIN-2-ONE DERIVATIVES, COMPOSITIONS WHICH PROTECT USEFUL PLANTS AND COMPRISE THESE DERIVATIVES, AND PROCESSES FOR THEIR PREPARATION AND THEIR USE | QSOX1, PRDX2, NQO2 | ALDH1A1 1311/4885ALOX15 1693/4885PTGS2 535/4885 |
| US-20040006047-A1 | Heterocyclic amides, a process for their preparation, compositions comprising them and their use | CBR1, HCN1, SCN1A | ALDH1A1 1221/4885ALOX15 3849/4885PTGS2 4389/4885 |
| US-20060173022-A1 | Heterocyclic amides, method for the production thereof, substances containing said heterocyclic amides, and use thereof as pesticides | CBR3, CBR1, C3AR1 | ALDH1A1 1821/4885ALOX15 1682/4885PTGS2 2795/4885 |
| US-20170129897-A1 | Pyrazolopyrimidine Derivatives Useful as Inhibitors of Bruton's Tyrosine Kinase | BTK, SYK, LCK | ALDH1A1 3044/4885ALOX15 2926/4885PTGS2 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.