Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | STS | P08842 | 1/20 | 0.31 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031497 | 0.82 | HSD11B1 (0.43) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL11148487 | 0.80 | HSD11B1 (0.46) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL329274 | 0.78 | HSD11B1 (0.41) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL1964873 | 0.76 | ALDH1A1 (0.43) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL329766 | 0.76 | HSD11B1 (0.44) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL329663 | 0.76 | HSD11B1 (0.44) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL329275 | 0.76 | HSD11B1 (0.44) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL11793191 | 0.76 | HSD11B1 (0.40) | HSD11B1ALDH1A1ALOX15KDM1AHDAC4 | |
| SCHEMBL11739223 | 0.74 | HSD11B1 (0.42) | HSD11B1ALDH1A1ALOX15HDAC4HDAC2 | |
| SCHEMBL329767 | 0.74 | HSD11B1 (0.46) | HSD11B1ALDH1A1ALOX15HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118851955-A | 2-Arylmethoxyiminocyclohexane sulfonamide compound, and preparation method and application thereof | 沈阳农业大学 | 2024-10-29 | — | — | CN | claimed |
| US-20230144068-A1 | METHOD FOR PREPARING MODIFIED VECTOR AND METHOD FOR MODIFYING VECTOR | KANEKA CORPORATION (JP) | 2023-05-11 | — | — | US | claimed |
| EP-0373951-B1 | PREPARATION OF 2,3-TRANS-1,4-BRIDGED CYCLOHEXANE SULFONAMIDE DERIVATIVES AND THEIR USE | SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD. (JP) | 1993-03-24 | — | — | EP | claimed |
| CN-118851955-A | 2-Arylmethoxyiminocyclohexane sulfonamide compound, and preparation method and application thereof | 沈阳农业大学 | 2024-10-29 | — | — | CN | disclosed |
| EP-3957627-B1 | 6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | SHIONOGI & CO (JP) | 2024-06-19 | — | — | EP | disclosed |
| US-11897899-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | SHIONOGI & CO., LTD. (JP) | 2024-02-13 | — | — | US | disclosed |
| EP-3495363-B1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT | SHIONOGI & CO (JP) | 2023-08-23 | — | — | EP | disclosed |
| US-11685740-B2 | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same | SHIONOGI & CO., LTD. (JP) | 2023-06-27 | — | — | US | disclosed |
| US-20230144068-A1 | METHOD FOR PREPARING MODIFIED VECTOR AND METHOD FOR MODIFYING VECTOR | KANEKA CORPORATION (JP) | 2023-05-11 | — | — | US | disclosed |
| US-11345716-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | SHIONOGI & CO., LTD. (JP) | 2022-05-31 | — | — | US | disclosed |
| CN-110072862-B | Bicyclic nitrogen-containing heterocyclic derivative and pharmaceutical composition containing the same | 盐野义制药株式会社 | 2022-05-13 | — | — | CN | disclosed |
| US-20200048257-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SHIONOGI & CO., LTD. (JP) | 2020-02-13 | — | — | US | disclosed |
| EP-3527568-A1 | BICYCLIC NITROGENATED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | Shionogi & Co., Ltd (JP) | 2019-08-21 | — | — | EP | disclosed |
| EP-3495363-A1 | NITROGEN-CONTAINING CONDENSED RING COMPOUND HAVING DOPAMINE D3 RECEPTOR ANTAGONISTIC EFFECT | Shionogi & Co., Ltd (JP) | 2019-06-12 | — | — | EP | disclosed |
| US-20190161501-A1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 ANTAGONISTIC EFFECT | SHIONOGI & CO., LTD. (JP) | 2019-05-30 | — | — | US | disclosed |
| US-20180118694-A1 | 6-MEMBERED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | SHIONOGI & CO., LTD. (JP) | 2018-05-03 | — | — | US | disclosed |
| EP-3287443-A1 | 6-MEMBERED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING SAME | Shionogi & Co., Ltd (JP) | 2018-02-28 | — | — | EP | disclosed |
| CN-1906162-B | Hydroxypiperidine derivatives for the treatment of Gaucher's disease | AMICUS THERAPEUTICS INC | 2012-05-23 | — | — | CN | disclosed |
| US-7901851-B2 | Colored curable composition, color filter and method of producing thereof | FUJIFILM CORPORATION (JP) | 2011-03-08 | — | — | US | disclosed |
| US-20070117031-A1 | Colored curable composition, color filter and method of producing thereof | FUJIFILM CORPORATION | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11345716-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | DRD3, DRD4, DRD2 | HSD11B1 1326/4885ALDH1A1 3610/4885ALOX15 4576/4885 |
| US-11897899-B2 | Nitrogen-containing condensed ring compounds having dopamine D3 antagonistic effect | DRD3, DRD4, DRD2 | HSD11B1 1326/4885ALDH1A1 3610/4885ALOX15 4576/4885 |
| US-20180118694-A1 | 6-MEMBERED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C1R, C1S | HSD11B1 636/4885ALDH1A1 2484/4885ALOX15 4017/4885 |
| US-20200048257-A1 | BICYCLIC NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | P2RX7, P2RX2, P2RX5 | HSD11B1 3352/4885ALDH1A1 2802/4885ALOX15 2624/4885 |
| US-11685740-B2 | Bicyclic nitrogen-containing heterocyclic derivatives and pharmaceutical composition comprising the same | P2RX7, P2RX2, P2RX1 | HSD11B1 2052/4885ALDH1A1 2890/4885ALOX15 2586/4885 |
| US-20190161501-A1 | NITROGEN-CONTAINING CONDENSED RING COMPOUNDS HAVING DOPAMINE D3 ANTAGONISTIC EFFECT | DRD3, DRD4, DRD2 | HSD11B1 1326/4885ALDH1A1 3610/4885ALOX15 4576/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.