Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.59 |
| ▸ | SKP1 | P63208 | 1/20 | 0.59 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ME3 | Q16798 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | DRD3 | P35462 | 2/20 | 0.51 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.51 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19658840 | 0.83 | DRD2 (0.65) | CKS1BSKP1SKP2EPHX2SMN1; SMN2 | |
| SCHEMBL17748966 | 0.82 | EPHX2 (0.61) | EPHX2SMN1; SMN2ME3ALDH1A1DRD2 | |
| SCHEMBL17830852 | 0.81 | CKS1B (0.61) | CKS1BSKP1SKP2EPHX2SMN1; SMN2 | |
| SCHEMBL17846438 | 0.80 | EPHX2 (0.58) | EPHX2SMN1; SMN2ME3ALDH1A1DRD2 | |
| SCHEMBL19652126 | 0.79 | CKS1B (0.63) | CKS1BSKP1SKP2SMN1; SMN2ALDH1A1 | |
| SCHEMBL3209065 | 0.79 | ME3 (0.63) | EPHX2SMN1; SMN2ME3DRD2DRD3 | |
| SCHEMBL25680457 | 0.79 | EPHX2 (0.54) | EPHX2SMN1; SMN2ME3ALDH1A1NPSR1 | |
| SCHEMBL13003260 | 0.78 | SIGMAR1 (0.68) | DRD2DRD3DRD4 | |
| SCHEMBL19652097 | 0.78 | MEN1 (0.55) | CKS1BSKP1SKP2ALDH1A1LMNA | |
| SCHEMBL3637427 | 0.77 | MTNR1A (0.61) | EPHX2SMN1; SMN2ME3DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | GENENTECH, INC. (US) | 2019-04-16 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2017-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10258603-B2 | Therapeutic compounds and uses thereof | BRD4, BRDT, BRD3 | CKS1B 239/4885SKP1 2240/4885SKP2 2256/4885 |
| US-20170340604-A1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | BRD4, BRDT, BRD3 | CKS1B 239/4885SKP1 2240/4885SKP2 2256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.