Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798174 | 0.83 | HPGD (0.59) | MAOAMAOBHPGDALDH1A1ALOX15 | |
| SCHEMBL2564071 | 0.80 | MAOA (0.48) | MAOAMAOBHPGDALDH1A1ALOX15 | |
| SCHEMBL110859 | 0.78 | CALM1 (0.52) | ALDH1A1HTR2ATAAR1LOXL2GRIN2B | |
| SCHEMBL28831761 | 0.76 | CALM1 (0.50) | ALDH1A1HTR2ATAAR1LOXL2GRIN2B | |
| Hydrochloric Acid SCHEMBL28817569 | 0.76 | CALM1 (0.50) | ALDH1A1SMN1; SMN2TAAR1LOXL2 | |
| SCHEMBL9741303 | 0.76 | ALDH1A1 (0.69) | MAOAMAOBHPGDALDH1A1ALOX15 | |
| SCHEMBL62125 | 0.76 | ALDH1A1 (0.69) | MAOAMAOBHPGDALDH1A1ALOX15 | |
| Benzene SCHEMBL3440179 | 0.76 | ALDH1A1 (0.69) | MAOAMAOBHPGDALDH1A1ALOX15 | |
| SCHEMBL7806865 | 0.76 | SIGMAR1 (0.48) | MAOAMAOBHPGDALDH1A1ALOX15 | |
| Hydrochloric Acid SCHEMBL14995271 | 0.74 | HTR2C (0.50) | MAOAMAOBALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443688-B1 | Spirodilactam-arylsulfone oligomers | SHELL INT RESEARCH (NL) | 1998-05-06 | — | — | EP | claimed |
| US-5059674-A | Cured arylcyclobutene ether spirodilactam | SHELL OIL COMPANY (US) | 1991-10-22 | — | — | US | claimed |
| EP-0443688-A2 | Spirodilactam-arylsulfone oligomers | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1991-08-28 | — | — | EP | claimed |
| US-4968810-A | Arylcyclobutene ethers | SHELL OIL COMPANY (US) | 1990-11-06 | — | — | US | claimed |
| US-4921931-A | Thermosetting resin compositions | SHELL OIL COMPANY (US) | 1990-05-01 | — | — | US | claimed |
| US-10202400-B2 | Cortistatin analogues and syntheses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-02-12 | — | — | US | disclosed |
| US-20170320886-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-11-09 | — | — | US | disclosed |
| US-9714255-B2 | Cortistatin analogues and syntheses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-07-25 | — | — | US | disclosed |
| US-20150376201-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-12-31 | — | — | US | disclosed |
| US-9127019-B2 | Cortistatin analogues and synthesis thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-09-08 | — | — | US | disclosed |
| US-20150111921-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEROF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-04-23 | — | — | US | disclosed |
| US-20110190323-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-08-04 | — | — | US | disclosed |
| EP-0397277-A2 | Modified bisphenols | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1990-11-14 | — | — | EP | disclosed |
| US-4960956-A | Modified bisphenols having at least one arylcyclobutenealkyl moiety and cured products therefrom | SHELL OIL COMPANY (US) | 1990-10-02 | — | — | US | disclosed |
| US-4788187-A | ANTISECRETORY AND ANTIULCEROGENIC AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1988-11-29 | — | — | US | disclosed |
| US-4743600-A | ANTIULCER, ANTISECRETORY | RORER PHARMACEUTICAL CORPORATION (US) | 1988-05-10 | — | — | US | disclosed |
| US-4639442-A | ANTIULCER | WILLIAM H. RORER, INC. (US) | 1987-01-27 | — | — | US | disclosed |
| EP-0182815-A4 | BENZOCYCLOBUTENE AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES. | RORER INTERNAT OVERSEAS INC (US) | 1986-10-14 | — | — | EP | disclosed |
| EP-0182815-A1 | BENZOCYCLOBUTENE AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1986-06-04 | — | — | EP | disclosed |
| WO-1985005032-A1 | BENZOCYCLOBUTENE AMINOALKYLENE ETHERS AND THIOETHERS, AND THEIR PHARMACEUTICAL USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1985-11-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150111921-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEROF | TEK, CTTN, FLT1 | MAOA 3600/4885MAOB 3699/4885HPGD 3200/4885 |
| US-20110190323-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | CTTN, TEK, PROKR1 | MAOA 2611/4885MAOB 3180/4885HPGD 2573/4885 |
| US-10202400-B2 | Cortistatin analogues and syntheses thereof | CTTN, TEK, FLT1 | MAOA 2742/4885MAOB 3127/4885HPGD 2779/4885 |
| US-20150376201-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | CTTN, TEK, FLT1 | MAOA 2742/4885MAOB 3127/4885HPGD 2779/4885 |
| US-20170320886-A1 | CORTISTATIN ANALOGUES AND SYNTHESES THEREOF | CTTN, TEK, FLT1 | MAOA 2742/4885MAOB 3127/4885HPGD 2779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.