Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 9/20 | 0.36 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15553924 | 0.87 | PTGS2 (0.35) | LMNAPTGS2ENPP2PTGS1WDR5 | |
| SCHEMBL11308558 | 0.76 | VCAM1 (0.44) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7044244 | 0.75 | LCK (0.43) | LMNAALDH1A1 | |
| SCHEMBL396496 | 0.75 | CA2 (0.54) | LMNA | |
| SCHEMBL1334156 | 0.74 | ENPP2 (0.48) | LMNAPTGS2ENPP2 | |
| SCHEMBL1272284 | 0.74 | PTGS2 (0.44) | LMNAPTGS2ENPP2PTGS1WDR5 | |
| SCHEMBL971270 | 0.73 | LMNA (0.42) | LMNAPTGS2ENPP2PTGS1ALDH1A1 | |
| SCHEMBL1638765 | 0.72 | ENPP2 (0.37) | LMNAPTGS2ENPP2 | |
| SCHEMBL2176609 | 0.72 | PTGS2 (0.33) | LMNAPTGS2ENPP2PTGS1 | |
| SCHEMBL5042103 | 0.70 | PTGS2 (0.38) | PTGS2ENPP2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2334683-B1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | MSD ITALIA SRL (IT) | 2017-03-22 | — | — | EP | disclosed |
| US-8470823-B2 | Saturated bicyclic heterocyclic derivatives as SMO antagonists | INSTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.R.L. (IT) | 2013-06-25 | — | — | US | disclosed |
| US-20110183989-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | Instituto di Ricerche di Biologia Molecolare P. Ang | 2011-07-28 | — | — | US | disclosed |
| EP-2334683-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | Istituto di ricerche di Biologia Molecolare P. Angeletti S.R.L. (IT) | 2011-06-22 | — | — | EP | disclosed |
| WO-2010023480-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2010-03-04 | — | — | WO | disclosed |
| EP-0877288-B1 | Silver halide light-sensitive color photographic material | KONISHIROKU PHOTO IND (JP) | 2004-12-01 | — | — | EP | disclosed |
| US-5998123-A | MERCAPTOPYRAZOLONE DERIVATIVE COUPLERS | KONICA CORPORATION (JP) | 1999-12-07 | — | — | US | disclosed |
| EP-0877288-A1 | Silver halide light-sensitive color photographic material | KONICA CORPORATION (JP) | 1998-11-11 | — | — | EP | disclosed |
| EP-0464612-B1 | Silver halide photographic materials | FUJI PHOTO FILM CO LTD (JP) | 1998-05-13 | — | — | EP | disclosed |
| US-5639900-A | MOLYBDENUM OR TUGSTEN COMPLEXES | METTON AMERICA, INC. (US) | 1997-06-17 | — | — | US | disclosed |
| US-4814261-A | Silver halide photographic material containing a development restrainer or a precursor thereof | FUJI PHOTO FILM CO., LTD. (JP) | 1989-03-21 | — | — | US | disclosed |
| EP-0295632-A2 | Silver halide color photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1988-12-21 | — | — | EP | disclosed |
| EP-0287073-A2 | Method for processing a silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-19 | — | — | EP | disclosed |
| EP-0285176-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-05 | — | — | EP | disclosed |
| EP-0284099-A2 | Silver halide color photographic materials | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-28 | — | — | EP | disclosed |
| EP-0281118-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-07 | — | — | EP | disclosed |
| US-4277559-A | FOR MASKING UNWANTED BLUE ABSORPTION OF MAGENTA DYES WITHOUT PRODUCING EXCESSIVE FOG | AGFA-GEVAERT N.V. (BE) | 1981-07-07 | — | — | US | disclosed |
| US-4199361-A | 3-ANILINO-5-PYRAZOLONE MAGENTA COLOR-FORMING COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1980-04-22 | — | — | US | disclosed |
| US-4137273-A | INSECTICIDES, CHEMICAL INTERMEDIATES | ZOECON CORPORATION (US) | 1979-01-30 | — | — | US | disclosed |
| US-4123281-A | Photographic silver halide color material containing fast-acting hardener and 2-pyrazolin-5-one coupler precursors | AGFA-GEVAERT N.V. (BE) | 1978-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183989-A1 | SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS | SMO, SHH, GLI1 | LMNA 4635/4885PTGS2 1023/4885ENPP2 2398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.