SCHEMBL1966405

SCHEMBL1966405

Cc1cc(-c2nnc(-c3ccccc3C(N)=O)s2)cc(C)c1C=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.40
NPC1 O15118 4/20 0.37
RAB9A P51151 4/20 0.37
ALDH1A1 P00352 2/20 0.37
LMNA P02545 1/20 0.37
CSNK1A1 P48729 1/20 0.36
TYRO3 Q06418 1/20 0.36
DYRK1B Q9Y463 1/20 0.36
CTSA P10619 4/20 0.36
DDX3X O00571 1/20 0.36
MKNK1 Q9BUB5 1/20 0.34
MKNK2 Q9HBH9 1/20 0.34
CA12 O43570 1/20 0.34
CA1 P00915 1/20 0.34
CA2 P00918 1/20 0.34
CA9 Q16790 1/20 0.34
RXFP1 Q9HBX9 1/20 0.34
EIF4E P06730 1/20 0.33
PTGES O14684 1/20 0.33
ALOX5 P09917 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1964639 0.81 ALDH1A1 (0.39) BCAT2NPC1RAB9AALDH1A1LMNA
SCHEMBL1965022 0.80 BCAT2 (0.44) BCAT2NPC1RAB9ACSNK1A1TYRO3
SCHEMBL18584726 0.79 BCAT2 (0.61) BCAT2NPC1RAB9ACSNK1A1TYRO3
SCHEMBL1968589 0.75 ALDH1A1 (0.40) BCAT2NPC1RAB9AALDH1A1LMNA
SCHEMBL1968944 0.73 BCAT2 (0.43) BCAT2NPC1RAB9ACSNK1A1TYRO3
SCHEMBL27758304 0.67 BCAT2 (0.59) BCAT2NPC1RAB9AALDH1A1CTSA
SCHEMBL11611572 0.67 NPC1 (0.56) NPC1RAB9AALDH1A1DDX3XCA12
SCHEMBL1270130 0.66 CTSA (0.50) BCAT2NPC1RAB9AALDH1A1LMNA
SCHEMBL2706854 0.65 TGFBR1 (0.51) BCAT2NPC1RAB9AALDH1A1LMNA
SCHEMBL28946413 0.65 ALDH1A1 (0.54) NPC1RAB9AALDH1A1LMNARXFP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2334670-A1 NEW 2-AMIDOTHIADIAZOLE DERIVATIVES Almirall S.A. (ES) 2011-06-22 EP disclosed