Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 11/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.37 |
| ▸ | GSK3A | P49840 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29802501 | 0.88 | PRKCQ (0.38) | PRKCQSIRT5L3MBTL1STK17AMEN1 | |
| SCHEMBL19665717 | 0.83 | JAK1 (0.37) | AURKA | |
| SCHEMBL19665731 | 0.83 | PIN1 (0.47) | PRKCQSIRT5L3MBTL1STK17ACYP1A2 | |
| SCHEMBL19665741 | 0.82 | GSK3A (0.47) | PRKCQSIRT5MEN1KMT2AGSK3B | |
| SCHEMBL19665714 | 0.82 | SIRT5 (0.53) | PRKCQSIRT5L3MBTL1STK17AMEN1 | |
| SCHEMBL28639475 | 0.82 | PRKCQ (0.41) | PRKCQSIRT5L3MBTL1STK17AMEN1 | |
| SCHEMBL19665763 | 0.80 | PRKCQ (0.46) | PRKCQSIRT5L3MBTL1STK17AMEN1 | |
| SCHEMBL19665630 | 0.76 | L3MBTL1 (0.44) | PRKCQSIRT5L3MBTL1STK17AMEN1 | |
| SCHEMBL28657267 | 0.75 | L3MBTL1 (0.47) | PRKCQSIRT5L3MBTL1STK17AMEN1 | |
| SCHEMBL19665633 | 0.74 | STK17A (0.53) | PRKCQSIRT5L3MBTL1STK17AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3464287-B1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2022-06-08 | — | — | EP | disclosed |
| US-11344554-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2022-05-31 | — | — | US | disclosed |
| US-20200330469-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2020-10-22 | — | — | US | disclosed |
| US-10736899-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2020-08-11 | — | — | US | disclosed |
| US-10420771-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2019-09-24 | — | — | US | disclosed |
| EP-3464287-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | Celgene Corporation (US) | 2019-04-10 | — | — | EP | disclosed |
| US-20180280398-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORP (US) | 2018-10-04 | — | — | US | disclosed |
| US-10016436-B2 | Animal and human anti-malarial agents | CELGENE CORPORATION (US) | 2018-07-10 | — | — | US | disclosed |
| WO-2017210399-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORPORATION (US) | 2017-12-07 | — | — | WO | disclosed |
| US-20170348316-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | CELGENE CORPORATION | 2017-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200330469-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, UMPS, PNP | PRKCQ 2957/4885SIRT5 2163/4885L3MBTL1 919/4885 |
| US-20170348316-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, NUDT1, UMPS | PRKCQ 3197/4885SIRT5 2434/4885L3MBTL1 622/4885 |
| US-10420771-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | PRKCQ 2856/4885SIRT5 2151/4885L3MBTL1 1006/4885 |
| US-10736899-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | PRKCQ 2957/4885SIRT5 2163/4885L3MBTL1 919/4885 |
| US-10016436-B2 | Animal and human anti-malarial agents | HPRT1, NUDT1, UMPS | PRKCQ 3197/4885SIRT5 2434/4885L3MBTL1 622/4885 |
| US-11344554-B2 | Animal and human anti-malarial agents | HPRT1, UMPS, PNP | PRKCQ 2957/4885SIRT5 2163/4885L3MBTL1 919/4885 |
| US-20180280398-A1 | ANIMAL AND HUMAN ANTI-MALARIAL AGENTS | HPRT1, UMPS, PNP | PRKCQ 2957/4885SIRT5 2163/4885L3MBTL1 919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.