Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669740 | 0.88 | LMNA (0.38) | SMN1; SMN2KMT2AMEN1LMNAEGFR | |
| SCHEMBL19912771 | 0.84 | PKM (0.36) | SMN1; SMN2LMNAEGFRALDH1A1KDM4E | |
| SCHEMBL15601075 | 0.84 | TP53 (0.38) | TP53KMT2AMEN1ALDH1A1L3MBTL1 | |
| SCHEMBL19912779 | 0.84 | SMN1; SMN2 (0.45) | SMN1; SMN2KMT2AMEN1LMNAEGFR | |
| SCHEMBL24637162 | 0.83 | EGFR (0.34) | SMN1; SMN2LMNAEGFRALDH1A1JAK2 | |
| SCHEMBL19442308 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2KMT2AMEN1LMNAEGFR | |
| SCHEMBL15600836 | 0.81 | SIGMAR1 (0.41) | SMN1; SMN2KMT2AMEN1LMNAEGFR | |
| SCHEMBL15600841 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2KMT2AMEN1EGFRALDH1A1 | |
| SCHEMBL19669739 | 0.79 | ALDH1A1 (0.35) | TP53LMNAEGFRALDH1A1POLB | |
| SCHEMBL20235763 | 0.79 | ACKR3 (0.35) | SMN1; SMN2KMT2AMEN1LMNAEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |