Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19669738 | 0.88 | SMN1; SMN2 (0.38) | LMNASMN1; SMN2EGFRKDM4EALDH1A1 | |
| SCHEMBL19912771 | 0.87 | PKM (0.36) | LMNASMN1; SMN2EGFRKDM4EALDH1A1 | |
| SCHEMBL19912779 | 0.87 | SMN1; SMN2 (0.45) | LMNASMN1; SMN2BTKEGFRERBB2 | |
| SCHEMBL24637162 | 0.86 | EGFR (0.34) | LMNATNIKSMN1; SMN2EGFRALDH1A1 | |
| SCHEMBL19442308 | 0.85 | SMN1; SMN2 (0.47) | LMNASMN1; SMN2BTKEGFRERBB2 | |
| SCHEMBL15601163 | 0.84 | KMT2A (0.36) | LMNASMN1; SMN2EGFRKDM4EALDH1A1 | |
| SCHEMBL15600836 | 0.83 | SIGMAR1 (0.41) | LMNASMN1; SMN2EGFRKDM4EALDH1A1 | |
| SCHEMBL14079970 | 0.83 | CHRNB2 (0.40) | TNIKBTKEGFRKDM4EERBB4 | |
| SCHEMBL15600841 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2BTKEGFRKDM4EERBB2 | |
| SCHEMBL19669739 | 0.82 | ALDH1A1 (0.35) | LMNAEGFRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834571-B2 | Compounds for inhibiting cell proliferation in EGFR-driven cancers | ARIAD PHARMACEUTICALS, INC. (US) | 2017-12-05 | — | — | US | disclosed |