Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.41 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.35 |
| ▸ | MPL | P40238 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SCD | O00767 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.35 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670141 | 0.84 | SCN9A (0.37) | — | |
| SCHEMBL19670214 | 0.84 | TRPA1 (0.38) | CNR2TRPA1TRPV3TRPV4MAPT | |
| SCHEMBL17618401 | 0.83 | CNR2 (0.44) | CNR2TRPA1TRPV3TRPV4KCNQ1 | |
| SCHEMBL19670209 | 0.82 | CNR2 (0.36) | CNR2TRPV3CNR1MAPTBRAF | |
| SCHEMBL19670579 | 0.81 | TRPA1 (0.36) | TRPA1TRPV3TRPV4BRAF | |
| SCHEMBL19670179 | 0.81 | HTR2C (0.46) | BRAF | |
| SCHEMBL19670221 | 0.81 | UBE2M (0.37) | TRPA1TRPV3TRPV4MAPTBRAF | |
| SCHEMBL19670412 | 0.81 | POLB (0.37) | CNR2TRPA1TRPV3TRPV4MAPT | |
| SCHEMBL19670135 | 0.81 | MEN1 (0.41) | MAPTBRAF | |
| SCHEMBL19670425 | 0.80 | KMT2A (0.39) | TRPV3MAPTBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |