Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 3/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | UBE2M | P61081 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.34 |
| ▸ | KDM1A | O60341 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670214 | 0.86 | TRPA1 (0.38) | TRPA1TRPV3TRPV4ADORA2ARAF1 | |
| SCHEMBL19670209 | 0.84 | CNR2 (0.36) | TRPV3ADORA2ARAF1BRAFMEN1 | |
| SCHEMBL19670310 | 0.84 | FAAH (0.38) | BRAFCA2CA9 | |
| SCHEMBL19670179 | 0.83 | HTR2C (0.46) | BRAFMEN1UBE2MKMT2ADCUN1D1 | |
| SCHEMBL19670221 | 0.83 | UBE2M (0.37) | TRPA1TRPV3TRPV4ADORA2ARAF1 | |
| SCHEMBL19670141 | 0.83 | SCN9A (0.37) | ADORA2AMEN1UBE2MKMT2ADCUN1D1 | |
| SCHEMBL19670135 | 0.83 | MEN1 (0.41) | ADORA2ARAF1BRAFMEN1UBE2M | |
| SCHEMBL19670412 | 0.83 | POLB (0.37) | TRPA1TRPV3TRPV4ADORA2ARAF1 | |
| SCHEMBL19670425 | 0.82 | KMT2A (0.39) | TRPV3ADORA2ARAF1BRAFMEN1 | |
| SCHEMBL19670629 | 0.82 | CA2 (0.40) | RAF1BRAFMEN1UBE2MKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |